Figure 5

Human therapeutic anti-factor Xa levels in sheep after administration of sodium enoxaparin (Groups 4a–b). A: After the administration of sodium enoxaparin in a concentration of 1 mg/kg bid (loading dose: 2 mg/kg, Group 4a), human therapeutic anti-factor Xa levels (0.6–1.0 IU/mL) could not be achieved (blue bars). There was a significant increase in anti-FXa levels comparing reference values with day 1 (p = 0.027) and 7 (p = 0.028). Between baseline and day 4 values did not differ significantly (one-way repeated measures ANOVA, post hoc Bonferroni Test). The administration of 3 mg/kg sodium enoxaparin (Group 4b) induced values within the human therapeutic range from day 4 on (green bars). A highly significant increase was seen between reference values and day 1 (p = 0.007), day 4 (p = 0.005) and 7 (p = 0.003), respectively. Between days 4 and 7, values did not differ significantly, indicating the formation of a steady state (one-way repeated measures ANOVA, post hoc Bonferroni Test). B: Measurement of the anti-factor Xa concentration throughout day 7 of treatment with 3 mg/kg sodium enoxaparin bid of 2 sheep. Peak plasma levels (0.94 ± 0.01 IU/mL) could be detected 2 hours after the administration of 3 mg/kg. Values rapidly decreased in the following hours to finally 0.08 ± 0.01 IU/mL 24 hours after injection.