Skip to main content

Table 4 Adverse events in toceranib treated dogs

From: Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose

Adverse event

Grade 1

Grade 2

Grade 3

Grade 4

Diarrhea

34

6

  

Vomiting

23

3

  

Neutropenia

20

1

  

Lethargy

15

2

  

Anorexia

15

1

  

Anemia

13

   

Increase ALP

9

2

1

 

Increase BUN

9

1

  

Increase ALT

7

 

1

1

Lameness

6

8

1

 

Increase AST

5

 

1

 

Protein losing nephropathy

4

   

Cough

4

   

Epistaxis

3

   

Panting

3

   

Ocular discharge

3

   

Weight loss

3

   

Hypertension

1

 

2

 

Thrombocytopenia

2

   

Hypopigmentation

2

   

Increase CK

2

   

Colitis

 

2

  

Hand-foot syndrome

1

   

Dermatitis

1

   

Alopecia

1

   

Ileus

  

1

 

Pancreatitis

  

1

 

Fever

 

1

  

Pruritus

1

   

Constipation

1

   

Constipation

188

27

8

1

Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us