Figure 1From: Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated doseToceranib plasma concentrations on day 30 of treatment. Shown are representative plasma toceranib concentrations from 4 dogs obtained on day 30 over 12 hours following drug administration. In this study, 28/40 dogs had Cmax at 6 or 8 hours on day 30. Two of the dogs shown experienced Cmax at 8 hours while the other two experienced Cmax after this time.Back to article page