Multiple alignment of the deduced amino acid sequences of silent information regulator 2 (Sir2) like family core region. The deduced amino acid sequences of Saccharomyces cerevisiae (s.c) Sir2 (NP_010242.1), cat (c) sirtuin (SIRT)1 and 3, dog (do) SIRT1 (XP_546130.2) and 3 (XP_855809.1), human (hu) SIRT1 (NP_036370.2) and 3 (NP_036371.1), mouse (mo) SIRT1 (NP_001153061.1) and 3 (NP_001171275.1), cow (co) SIRT1 (NP_001179909.1) and 3 (NP_001193598.1), pig (pi) SIRT1 (NP_001139222.1) and 3 (NP_001103527.1), chicken (ch) SIRT1 (NP_001004767.1) and 3, (NP_001186422.1), and zebrafish SIRT1 (XP_001334440.4) and 3 (NP_001073643.1). Starting and ending residue numbers are shown. Black shaded background indicates 100% homology, whereas gray shaded backgrounds indicate >50% homology. The GAGxSxxxGIPDFR, TQNID, HG(S/T), and CxxC-(18–20)x-CxxC motifs are indicated with the box. The nucleotide sequences appear in the GenBank database with accession numbers (caSIRT1) and (caSIRT3).