Plasma metabolomic profiling of dairy cows affected with ketosis using gas chromatography/mass spectrometry

BMC Veterinary Research

Table 3 The potential diagnostic biomarkers of any two groups of CK, SK, and NC

No	Compounds^a	CK vsNC		SK vsNC		CK vsSK
No	Compounds^a	LR+^b	AUC^c	LR+^b	AUC^c	LR+^b	AUC^c
1	GA	0.25	0.122	0.38	0.176
2	L-ala	0.06	0.149			0.30	0.216
3	L-ser					0.36	0.240
4	GLCA	0.19	0.153	0.05	0.19
5	Erythritol	0.28	0.161
6	Ribitol	0.26	0.171
7	Glc	0.24	0.176	1.07	0.259
8	LA	0.07	0.178	0.18	0.199
9	Gal	0.34	0.184	0.42	0.22
10	GABA	0.15	0.221			0.26	0.261
11	DHB					0.36	0.257
12	THB	0.38	0.231
13	pGlu	0.47	0.269
14	MMA			1.01	0.283
15	Melibiose	1.05	0.277
16	Citrate					0.42	0.281
17	3HV			2.32	0.79
18	AABA			11.80	0.79
19	L-leu	1.89	0.638
20	Xylitol	3.16	0.752
21	Gly	2.33	0.76	7.90	0.837
22	2Me3HB	3.60	0.764
23	AMA	2.57	0.773	3.09	0.822
24	AABA	1.05	0.773
25	αTP	2.37	0.783
26	L-ile	3.16	0.814	3.32	0.827
27	HMG	4.07	0.848
28	Sitosterol	3.00	0.88			1.91	0.741
29	PA	6.35	0.897	5.29	0.838
30	C-9-HA	3.81	0.909	2.75	0.842
31	Hep	7.02	0.911	5.15	0.866
32	MA	6.01	0.913	3.21	0.845
33	SA	6.35	0.913	3.44	0.842
34	2PC	4.97	0.918	7.78	0.923
35	T-9-OA	4.21	0.924	3.58	0.868
36	3HV	9.09	0.95			2.38	0.764
37	BHBA	10.22	0.977	8.13	0.965	5.11	0.953

^aAbbreviations of compounds’ name are same as Table 2.
^b+LR, positive likelihood ratio.
^cAUC, area under the curve. If AUC value is more than 7.00 or less than 0.30, compound is considered to be a potential diagnostic biomarker of disease.

ISSN: 1746-6148