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Table 2 Geometric mean (± SD, n = 6) flunixin meglumine pharmacokinetic parameters after a single intravenous (IV), intramuscular (IM) or oral (PO) administration in gilts (2.2 mg/kg -1)

From: Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration

Parameter

Units

Administration Route

  

IV

±SD

IM

±SD

PO

±SD

AUC EXTRAP

%

0.1

0.08

0.5

1.2

0.6

0.29

AUC INF

h*ng/ml

21635

3966.7

16849

4257.7

4836

2333.0

C0 d

ng/ml

24960

5378.2

-

-

-

-

Cl e

h

1.68

0.38

-

-

-

-

T ½ λz

h

6.29

1.03

7.49

2.54

7.08

1.33

λz

1/h

0.11

0.01

0.09

0.03

0.10

0.02

MRT 0-INF

h

3.01

0.63

6.41

1.85

5.58

0.86

Vss

l/kg

0.30

0.07

-

-

-

-

Vz

l/kg

0.91

0.26

-

-

-

-

CMax

ng/ml

  

3748

1110.8

946

401.2

TMax

h

  

0.61

0.59

1.00

0.75

F

 

-

-

0.76

0.02

0.22

0.11

  1. Flunixin meglumine noncompartmental pharmacokinetics (WinNonlin 5.2, Pharsight Inc. Cary NC, USA). AUC extrapolated percent of the AUC extrapolated, AUC INF area under the curve extrapolated to infinity, CMAX maximum plasma concentration, T ½ λz terminal half-life, λz terminal rate constant, MRT mean residence time extrapolated to infinity, TMAX time to CMAX, F fraction of the dose absorbed.
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BMC Veterinary Research

ISSN: 1746-6148

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