Table 1 Average incubation times and survival percentages of tg a 20 mice inoculated intracranially with serially diluted or treated RML scrapie brain homogenate
Group | Dilution or treatment | Mean incubation time in days ± SD (% survival) |
|---|---|---|
RML titration series * | ||
100 | 66 ± 3.4 (0%) | |
10-1 | 74 ± 3.3 (0%) | |
10-2 | 83 ± 6.1 (0%) | |
10-3 | 128 ± 29.1 (22%) | |
10-4 | 184 ± 39.6 (78%) | |
10-5 through 10-12 | N/A (100%) – study termination | |
Treated RML | ||
SPC-PL* | 67 ± 2.6 (0%) | |
SPC-PH* | 70 ± 6.0 (0%) | |
SPC-PL + SDS* | 93 ± 9.7 (0%) | |
SPC-PH + SDS* | 93 ± 7.6 (0%) | |
1 | SPC-PL ∏ PK | 107 ± 39.0 (11%) |
2 | SPC-PH ∏ PK | 98 ± 16.8 (0%) |
3 | SPC-PL + SDS ∏ PK | 431 ± 72.4 (73%) |
4 | SPC-PH + SDS ∏ PK | 108^ (88%) |
5 | SDS control | 85 ± 12.3 (0%) |
6 | PK control | 62 ± 5.2 (0%) |
7 | SDS ∏ PK control | 86 ± 7.1 (0%) |