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Table 1 Average incubation times and survival percentages of tg a 20 mice inoculated intracranially with serially diluted or treated RML scrapie brain homogenate

From: Evaluation of a combinatorial approach to prion inactivation using an oxidizing agent, SDS, and proteinase K

Group Dilution or treatment Mean incubation time in days ± SD (% survival)
  RML titration series *  
  100 66 ± 3.4 (0%)
  10-1 74 ± 3.3 (0%)
  10-2 83 ± 6.1 (0%)
  10-3 128 ± 29.1 (22%)
  10-4 184 ± 39.6 (78%)
  10-5 through 10-12 N/A (100%) – study termination
  Treated RML  
  SPC-PL* 67 ± 2.6 (0%)
  SPC-PH* 70 ± 6.0 (0%)
  SPC-PL + SDS* 93 ± 9.7 (0%)
  SPC-PH + SDS* 93 ± 7.6 (0%)
1 SPC-PL ∏ PK 107 ± 39.0 (11%)
2 SPC-PH ∏ PK 98 ± 16.8 (0%)
3 SPC-PL + SDS ∏ PK 431 ± 72.4 (73%)
4 SPC-PH + SDS ∏ PK 108^ (88%)
5 SDS control 85 ± 12.3 (0%)
6 PK control 62 ± 5.2 (0%)
7 SDS ∏ PK control 86 ± 7.1 (0%)
  1. *Smith et al.[29]; ^only 1 mouse in this group was euthanized due to clinical scrapie.
  2. SD standard deviation.