Skip to main content

Table 2 Pharmacokinetic parameters of buprenorphine after 0.0075 mg/kg bwt intravenously in ten horses

From: Nociceptive thermal threshold testing in horses – effect of neuroleptic sedation and neuroleptanalgesia at different stimulation sites

Horse λz(h-1) T1/2λ(h) Vd(L/kg) Cl (mL/min/kg) AUC0-∞(h·ng/mL) MRT (h)
1 0.12 7.02 3.89 6.40 19.54 6.98
2 0.06 12.09 1.88 1.80 69.39 12.48
3 0.06 8.86 2.90 3.78 33.12 9.25
4 0.12 5.59 0.83 1.71 72.93 5.12
5 0.12 6.79 1.03 1.76 71.17 6.54
6 0.18 3.51 0.56 1.84 67.91 3.47
7 0.06 9.89 3.07 3.59 34.81 11.96
8 0.12 6.85 0.92 1.56 80.33 7.61
9 0.18 4.30 1.69 4.55 27.47 5.09
10 0.12 7.47 3.74 5.78 21.62 9.56
Mean ± SD 0.11 ± 0.04 6.4 ± 2.63* 2.05 ± 1.25 3.28 ± 1.82 49.83 ± 24.37 7.81 ± 2.98
  1. λz, slope of the terminal phase; T1/2λ, half-life of terminal phase; Vd(area), volume of distribution; Cl, Clearance; AUC0-∞, area under the concentration-time curve extrapolated to infinity; MRT mean residence time. *Harmonic mean ± pseudo SD.