Figure 3

The pedigree of Shiba Inu dogs with GM1 gangliosidosis. The 23 affected dogs (A1–A23) are from the Hokkaido (H), Kinki (Ki), Chugoku (Cg), Kanto (Ka), Shikoku (S), and Kyushu (Ky) districts. Pedigree information was not available for 5 affected dogs (A9, A10, A17, A18, and A21). Two carriers (C1-Ka and C2-Ki) were identified in the Kanto and Kinki districts, respectively, in the molecular epidemiological survey of this study. * Carriers from a specific kennel, which are related to a number of affected and carrier offspring in the Kinki district.