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Table 2 Results of univariate/multivariate analysis of factors associated with clinical outcome

From: HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors

Univariate analysis
  Median DFI (d) HR P 95% CI
HES1 Score <4 155 0.388 0.0023 0.211-0.712
  ≥4 258    
BALP <36 273.5 1.871 0.0377 1.036-3.378
  ≥36 157    
Necrosis% <20% 239 1.799 0.098 0.897-3.609
  ≥20% 168    
Mitotic Index <54 258 3.234 0.0163 1.241-8.428
  ≥54 153    
Grade 1 or 2 308 15.43 <0.0001 4.243-56.07
  3 75    
Multivariate analysis
    HR P 95% CI
HES1 Score    0.775 0.029 0.616-0.975
Necrosis%    1.032 0.002 1.012-1.053
Mitotic Index   1.033 0.005 1.01-1.057
  1. DFI disease free interval, BALP bone-specific alkaline phosphatase.