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Table 2 Results of univariate/multivariate analysis of factors associated with clinical outcome

From: HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors

Univariate analysis

 

Median DFI (d)

HR

P

95% CI

HES1 Score

<4

155

0.388

0.0023

0.211-0.712

 

≥4

258

   

BALP

<36

273.5

1.871

0.0377

1.036-3.378

 

≥36

157

   

Necrosis%

<20%

239

1.799

0.098

0.897-3.609

 

≥20%

168

   

Mitotic Index

<54

258

3.234

0.0163

1.241-8.428

 

≥54

153

   

Grade

1 or 2

308

15.43

<0.0001

4.243-56.07

 

3

75

   

Multivariate analysis

   

HR

P

95% CI

HES1 Score

  

0.775

0.029

0.616-0.975

Necrosis%

  

1.032

0.002

1.012-1.053

Mitotic Index

 

1.033

0.005

1.01-1.057

  1. DFI disease free interval, BALP bone-specific alkaline phosphatase.