Table 7 Semiquantitative scoring systems for murine hepatic and pancreatic disease models
Disease model | Scoring system: parameters (scale width) | Citations |
|---|---|---|
Hepatic disease | ||
Chronic active hepatitis [107] | Periportal bridging (0–10), intralobular necrosis, portal inflammation, fibrosis (each 0–4) | 2,609 |
Chronic hepatitis [106] | Periportal/septal inflammation (0–4), confluent necrosis (0–6), focal necrosis/apoptosis/inflammation (0–6), portal inflammation (0–4), fibrosis (0–6) | 2,001 |
Chronic hepatitis [110] | Mitotic activity, portal inflammation, ductular proliferation, councilman bodies, fibrosis (each 0–3) | 107 |
Hepatic fibrosis [108] | Centrolobular vein/perisinusoidal space fibrosis (each 0–2), portal tract fibrosis (0–3), septa number (0–3), septa width (0–5) | 135 |
Acute hepatitis [111] | Steatosis (0–4), necrosis, inflammation (each 0–2), | 218 |
Acute hepatitis [109] | Portal/lobular inflammation (each 0–3) | 41 |
Nutritional hepatopathy [112] | Hepatocyte degeneration, portal inflammation, portal fibrosis (each 0–3) | 25 |
Alcohol-induced hepatopathy [113] | Steatosis (%), inflammation/necrosis/fibrosis (each 0–2) | 8 |
Non-alcoholic Steatohepatitis [114] | Steatosis (0–3), hepatocellular ballooning (0–2), lobular inflammation (0–2) | 1,149 |
Hepatic ischemia [115] | Location, necrosis (together 0–4) | 12 |
Pancreatic disease | ||
Acute pancreatits [116] | Edema, necrosis, inflammation, hemorrhage, fat necrosis (each 0–4) | 307 |
Acute pancreatitis [117] | Edema, necrosis, inflammation, vacuolization (each 0–4) | 144 |
Acute pancreatitis [118] | Edema, necrosis, inflammation, hemorrhage (each 0–4) | 89 |
Acute pancreatitis [119] | Acinar-cell ghosts (%), acinar cells vacuolization/swelling (%) | 42 |
Ischemia-induced acute pancreatitis [120] | Edema, necrosis, infiltration, hemorrhage, vacuolization (each 0–3) | 14 |
Autoimmune pancreatitis [121] | Infiltration, necrosis, lipomatosis (0–4) | 42 |
Insulitis [122] | Islet infiltration, destruction, atrophy (0–5) | 49 |