Table 6 Semiquantitative scoring systems for cardiovascular and muscle disease models
Disease model | Scoring system: parameters (scale width) | Citations |
|---|---|---|
Myocardial diseases | ||
EMCV-induced myocarditis [96] | Myocardial necrosis, infiltration, calcification, fibrosis (together 0–4) | 50 |
Coxsackievirus-induced myocarditis [97] | Myocardial necrosis, infiltration, calcification (together 0–4) | 33 |
Coxsackievirus-induced myocarditis [98] | Necrosis, inflammation, Evans blue-stain (each 0–4) | 17 |
Dilated cardiomyopathy [99] | Myocardial necrosis, fibrosis (together 0–4) | 20 |
Chronic cardiotoxicity [100] | Qualitative/quantitative myocardial degeneration score (each 0–4) | 72 |
Vascular diseases | ||
Aneurysm [101] | Extent of medial, adventitial disruption/size of lesion (together 0–6) | 21 |
Atherosclerosis [102] | Medial erosion, foam cells, buried fibrous caps, chondrocyte-like cells, lateral xanthomas (each 0,1) | 2 |
Vasculitis [103] | Infiltration, elastic lamina destruction, intimal thickening (together 0–3) | 8 |
Muscle diseases | ||
Ischemic necrosis [104] | Infiltration, necrosis, hemorrhage (together 0–10) | 14 |
Trypanosoma myositis [105] | Number of parasites, eosinophilic infiltration (each 0–3) | 0 |