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Table 5 Semiquantitative scoring systems for murine models of pulmonary diseases

From: Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review

Pulmonary disease models

Scoring system: parameters (scale width)

Citations

Lung fibrosis [83]

Alveolar/bronchial wall thickening, structure distortion, fibrosis (together 0–8)

273

Lung fibrosis [84]

Fibroblastic foci, established fibrosis, intraalveolar macrophages (each 0–6)

116

Cystic fibrosis [85]

Lymphoid infiltrate (0–5), goblet cell hyperplasia (0–2), mucus retention (0–3), bronchiolitis (0–5), pneumonia (0–3), edema (0–2)

101

Ventilator-induced lung injury [86]

Alveolar congestion, hemorrhage, neutrophils in airspaces/vessel walls, alveolar wall thickness, hyaline membranes (each 0–4)

78

Pulmonary ischemia [87]

Edema, inflammatory cell infiltration, vascular congestion, alveolar hemorrhage (each 0–3)

5

Smoke-induced pneumopathy [88]

Alveolar emphysema, atelectasis, infiltration, hemorrhage, alveolar wall thickness, perivascular/peribronchiolar edema (each 0–3)

4

Lung inflammation [89]

Perivascular edema (0–3), perivascular/-bronchiolar inflammation (0–3), goblet cell metaplasia (0–2)

32

Lung inflammation [90]

Alvolear wall inflammation, perivenous regions, periarterial/peribronchial regions, venous/arterial endothelial lesion (each 0–3)

30

Acute lung inflammation [91]

Alveolar necrosis, vascular congestion, infiltration by neutrophils/ macrophages (each 0–4)

6

RSV pneumonia [92]

Peribronchiolitis, alveolitis, perivasculitis, hypertrophy of mucus-producing glands, eosinophilia (each 0–5).

26

Mycoplasma pneumonia [93]

Quantity/quality of (peri-)bronchial infiltrates, bronchial luminal exudate, perivascular infiltrate, parenchymal pneumonia (0–3)

56

Pneumocystis carinii infection [94]

Cyst number (0–4), inflammation (0–5)

87

Streptococcus pneumonia [95]

Bronchitis, edema, interstitial inflammation, intraalveolar inflammation, pleuritis, endothelialitis (each 0–4)

0