Table 3 Semiquantitative scoring systems for murine renal disease models
Renal disease model | Scoring system: parameters (scale width) | Citation |
|---|---|---|
Lupus nephritis [48] | Activity index (glomerular/tubulointerstitial abnormalities (6-tier, each 0–4)); chronicity index (4-tier, each 0–3) | 358 |
Lupus nephritis [49] | Mesangial thickening, extent of changes (together 0–4) | 44 |
Lupus nephritis [50] | Glomerular cell proliferation, lobulation, hyaline droplets, macrophage infiltration (together 0–3) | 25 |
Lupus nephritis [51] | Glomerular inflammation, proliferation, crescent formation, necrosis (each 0–3) | 1 |
Toxic nephropathy [52] | Glomerular cellularity, hypertrophy, thrombosis, dilation (together 0–5) | 4 |
Toxic nephropathy [53] | Glomerular injury, tubular cysts/casts, podocyte hyperplasia, interstitial inflammation (each 0–4) | 33 |
Hypertension nephropathy [54] | Mesangial matrix, percentage of glomerular affection (each 0–4) | 524 |
Diabetic-/Hypertension-induced glomerulosclerosis [55] | Arteriole hyalinization, glomerular sclerosis (0–4), interstitial volume (%) | 152 |
Diabetic nephropathy [56] | Glomerulosclerosis, interstitial fibrosis (each 0–4) | 15 |
Crescentic glomerulonephritis[57] | Fibrin deposition, immunoglobulin deposition, tubular damage, glomerular crescents (each 0–3) | 8 |
MRL/MPJ mouse glomerulonephritis [58] | Glomerular infiltration, crescents, necrosis, tubular casts, interstitial infiltrates (each 0–4) | 244 |
Age-associated changes [59] | Mesangial proliferation, sclerosis, hyalinization (together 0–5) | 27 |
HIV-nephropathy [60] | Tubuloepithelial degeneration/regeneration, tubular casts, dilation, interstitial infiltration, glomerular sclerosis, collapse, podocyte hyperplasia (each 0–3) | 47 |
Obstructive nephropathy [61] | Tubular dilation/atrophy, interstitial fibrosis (each 0–3) | 4 |