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Table 2 Semiquantitative scoring systems for murine osteoarthritis models

From: Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review

Osteoarthritis model

Scoring system: parameters (scale width)

Citations

Arthritis [28]

Cartilage structure (0–6), cells (0–3), Safranin-O-stain (0–4), tidemark integrity (0–1)

1322

Arthritis [30]

Cartilage destruction (0–6), optional subgrading (subdivision in 2 subgrades)

197

Arthritis [31]

Synovial lining, resident cell density, inflammation (each 0–3)

49

Collagen-induced [29]

Extent of synovitis, cartilage loss, bone erosions (together 0–3)

713

Collagen-induced [32]

Inflammation, cartilage destruction, bone erosion (each 0–3)

273

Collagen-induced [33]

Infiltration in the exudate, infiltration of the synovial membrane, cartilage destruction, bone erosion (each 0–3)

198

Collagen-induced [34]

Joint exudate (0–5), proteoglycan depletion (0–3)

139

Collagen-induced [35]

Bone resorption, inflammation, cartilage damage (each 0–5)

95

Mycobacterium butyricum-induced [36]

Synovial thickening, infiltration, pannus formation (each 0–3)

95

Adjuvant-induced [37]

Percentage of affected area, synovial hyperplasia, cartilage destruction, bone erosion (each 0–3)

64

IL1-induced arthritis [38]

Synovial infiltration, proteoglycan depletion, cartilage damage (each 0–3)

41

Instability-induced [39]

Matrix structure, matrix staining, cellularity, subchondral bone (each 0–8)

85

Instability-induced [40]

Cartilage destruction (0–4), osteophyte formation (0–3)

85

Hereditary arthritis [41]

Articular cartilage structure (0–8), Toluidine blue-staining (0–6)

52

Bacterial arthritis [42]

Infiltration (0–4), pannus formation, cartilage destruction, extra-articular manifestations, tail lesion (each 0,1)

145

Cartilage repair [43]

Cell morphology (0–4), matrix staining (0–3), surface regularity (0–3), thickness (0–2), integration of donor cartilage (0–2)

819

Cartilage repair [44]

Cellular morphology (0,2,4), Safranin-O stain (0–3), structural regularity (0–3), structural integrity (0–2), thickness (0–2), bonding (0–2), hypocellularity (0–3), chondrocyte clustering (0–2), adjacent degeneration (0–3)

297

Cartilage repair [45]

Relative defect area (0–4), integration of repair tissue (0–3), matrix staining (0–4), cellular morphology (0–5), defect architecture (0–4), surface architecture, percentage of new bone (0–4), tidemark formation (0–4)

222

Cartilage repair [46]

Filled depth (0–4), integration (0–2), surface architecture (0–3), cell morphology (0–3), cellularity (0–2), tidemark formation (0–4), Toloudin blue stain (0–2)

130

Cartilage repair [47]

Defect filling (0–4), osteochondral reconstruction (0–2), matrix staining (0–4), cell morphology (0–4)

96

  1. IL1, Interleukin 1.