Table 1 Semiquantitative scoring systems for murine intestinal disease models
Disease model | Scoring system: parameters (scale width) | Citations |
|---|---|---|
Colitis | ||
DSS-induced [4] | Proximal + middle + distal colon: crypt loss (0–4), inflammation (0–3) both quantified by the affected area (0–4) | 718 |
DSS-induced [5] | Extent, inflammation, necrosis, regeneration (each 3–0) | 321 |
DSS-induced [6] | Crypt damage, area involved, regeneration (each 0–4), extent (0–3), inflammation (0–3), | 255 |
DSS-induced [7] | Crypt loss (0–4), crypt distortion (0–4), epithelial hyperplasia (0–4), inflammation (0–3) each multiplied by percentage of involved area (0–4) | 185 |
DSS-induced [8] | Hyperplasia (0–3), severity (0–3), ulceration (0,1), area involved (0–4) | 147 |
DSS-induced [9] | Severity of inflammation, thickness of inflammation, epithelial damage character, extent of epithelial damage (each 0–3) | 130 |
DSS-induced [10] | Epithelium (goblet cell/crypt loss), infiltration (each 0–4) | 103 |
DSS-induced [11] | Infiltration, tissue damage (each 0–3) | 89 |
TNBS-induced [12] | Inflammation, loss of goblet cells, vascular density, transmural infiltration, thickening of the colon wall (together 0–4) | 788 |
TNBS-induced [13] | Crypt distortion, goblet cell loss, acute inflammation, chronic inflammation (each 0–2) | 126 |
TNBS-induced [14] | Loss of mucosal architecture, cellular infiltration, muscle thickening (each 0–3), crypt abscesses (0,1), goblet cell depletion (0,1) | 97 |
Acetic acid-induced [15] | Inflammation, bleeding, ulcer size, deepness, perforation (together 0–6) | 132 |
TNBS-induced [16] | Percentage of area, crypt loss (both 0–4) number of follicles, edema, erosion/ulceration, infiltration (each 0–3) | 57 |
HLA-B27 transgenic mice [17] | Inflammation, goblet cell loss, mucosal thickening, submucosal infiltration, architecture loss (each 0–4), ulcer, crypt abscess (each 0,1) | 423 |
IL10-deficient mice [18] | Mucosal ulceration, epithelial hyperplasia (both 0–3), Lamina propria mononuclear infiltrate, Lamina propria neutrophil infiltrate (each 0–2) | 423 |
IL10-deficient mice [19] | Inflammation/epithelial erosion/ulcers/hyperplasia/crypt abscesses/goblet cell depletion (together 0–4) multiplied by no. of affected colon segments (1–5) | 555 |
MHC missmatch [20] | Active inflammation (0.5-3), chronic inflammation (0.5-3), villous architecture (1–3) multiplied by the affected area (0.5-4) | 83 |
Amebic colitis [21] | Number of amoeba (0–5), ulceration (0-100%), inflammation (0–5) | 58 |
Small intestinal diseases | ||
Clostridial toxicosis [22] | Epithelial damage, hyperemia/edema, neutrophils (each 0–3) | 202 |
Intestinal ischemia [23] | Normal mucosa (0), villous edema (1), subepithelial edema (2), epithelium loss at villi sides (3), denuded villi (4), loss of villous tissue (5), crypt infarction (6), transmucosal infarct (7), transmural infarct (8) | 270 |
Intestinal ischemia [24] | Mucosal damage, inflammation, hyperemia/hemorrhage (each 0–5) | 72 |
Jejunitis [25] | Villous length, villous tips, epithelium, inflammation, crypt loss (each 0–2), crypt abscesses, hemorrhage (each 0,1) | 15 |
Bacterial ileitis [26] | Hemorrhage, villous atrophy/necrosis, edema, congestion, neutrophils, epithelial necrosis (each 0–3) | 1 |
Gastric diseases | ||
Helicobacter-induced [27] | Five areas multiplied by inflammation (0–3) | 49 |