Table 2 Significantly enriched KEGG pathway’s classes for the 109 genes with over-expressed expression and for the 86 genes with under-expressed expression in affected animals versus healthy controls (Count threshold =2, EASE threshold = 0.05)
From: Microarray gene expression profiling of neural tissues in bovine spastic paresis
| Â | C1 class | C2 class | C3 class | Genes | p-value |
|---|---|---|---|---|---|
over-expressed | Cellular Processes | Cell Communication | Focal adhesion | LOC518180, COL4A2, COL1A2, PRKCG, LAMC2, BAD, THBS1, AKT2 | 0.0005 |
Human Diseases | Cancers | Pathways in cancer | LOC518180, DVL2, COL4A2, PRKCG, LAMC2, BCL2L1, BAD, AKT2, DAPK1 | 0.0021 | |
Organismal Systems | Nervous System | Neurotrophin signaling pathway | LOC518180, ATF4, SH2B3, BAD, CAMK2A, AKT2 | 0.0021 | |
Environmental Information Processing | Signaling Molecules and Interaction | ECM-receptor interaction | COL4A2, SDC1, COL1A2, LAMC2, THBS1 | 0.0027 | |
Environmental Information Processing | Signal Transduction | ErbBsignaling pathway | LOC518180, PRKCG, BAD, CAMK2A, AKT2 | 0.0031 | |
Human Diseases | Cancers | Chronic myeloid leukemia | LOC518180, BCL2L1, BAD, AKT2 | 0.020 | |
under-expressed | Human Diseases | Neurodegenerative Diseases | Amyotrophic lateral sclerosis (ALS) | DERL1, NEFH, NEFL | 0.016 |