Table 3 Expression of pgp, bcrp, mrp1 and mrp3 in various experimental conditions

PGP

ctrl

3.50

9.20

5.00

17.85

16.42

pgp siRNA

0.45***

0.10***

0.50***

0.80***

0.16***

non-coding siRNA

3.44

9.10

5.10

7.750

16.31

vinblastine

9.50***

16.20***

14.70***

19.56***

21.52***

cisplatin

8.95***

35.20***

31.00***

36.08***

26.16***

cyclophosphamide

0.09***

2.30**

0.22***

0.08***

2.87***

BCRP

ctrl

19.84

11.86

23.52

23.70

36.00

bcrp siRNA

17.15**

2.77***

2.77***

10.46***

0.00***

non-coding siRNA

19.00

11.20

22.90

23.00

36.18

vinblastine

14.84*

3.80***

11.80***

12.30***

13.24*

cisplatin

30.50***

22.16***

40.34***

36.57***

37.23*

cyclophosphamide

23.32***

33.53*

29.23***

24.50*

41.72**

MRP1

ctrl

7.50

9.40

16.50

20.10

24.02

mrp1 siRNA

0.10***

0.60***

0.23***

0.20***

0.61***

non-coding siRNA

7.20

6.62

20.12

20.91

24.21

vinblastine

9.70***

7.00***

9.76***

35.01*

30.20***

cisplatin

15.70***

19.34**

21.84*

30.61***

26.20**

cyclophosphamide

2.50**

0.09***

3.32***

↓0.40***

6.04**

MRP3

ctrl

14.40

23.28

13.84

17.70

11.35

mrp3 siRNA

1.00***

0.00***

4.84***

13.90**

7.15**

non-coding siRNA

13.87

21.99

13.09

17.10

10.99

vinblastine

14.20

21.97

13.12

17.50

9.78

cisplatin

15.60*

32.20***

15.80*

21.30***

14.09*

cyclophosphamide

14.99

24.09

14.25

18.01

11.72