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Table 8 Estimated changes in muscle damage indicators (AST, LDH, and CK) and body weight one and two days after procedures

From: Comparison of three different sedative-anaesthetic protocols (ketamine, ketamine-medetomidine and alphaxalone) in common marmosets (Callithrix jacchus)

Day 1       
AST Est (95% CI) PC P1 P2 P3A P3B
PC 198.8 (8.5 to 389.1)   ** NS *** NS
P1 526.0 (335.7 to 716.3) **   *** *** *
P2 79.4 (−110.9 to 269.7) NS ***   *** NS
P3A 1123.2 (932.9 to 1313.5) *** *** ***   ***
P3B 246.4 (56.1 to 436.7) NS * NS ***  
LDH Est (95% CI) PC P1 P2 P3A P3B
PC 78.5 (−119.6 to 276.6)   NS NS *** NS
P1 299.2 (101.1 to 497.3) NS   NS *** NS
P2 40.0 (−158.1 to 238.1) NS NS   *** NS
P3A 795.4 (597.3 to 993.5) *** *** ***   ***
P3B 43.3 (−154.8 to 241.4) NS NS NS ***  
CK Est (95% CI) PC P1 P2 P3A P3B
PC 7.2 (4.0 to 12.9)   *** NS *** NS
P1 37.8 (21.1 to 67.7) ***   *** NS **
P2 3.9 (2.2 to 7.0) NS ***   *** *
P3A 74.2 (41.5 to 132.8) *** NS ***   ***
P3B 11.0 (6.2 to 19.7) NS ** * ***  
Body Weight Est (95% CI) PC P1 P2 P3A P3B
PC −0.9 (−4.5 to 2.7)   NS NS ** NS
P1 0.5 (−3.1 to 4.1) NS   NS *** *
P2 1.8 (−1.8 to 5.4) NS NS   *** **
P3A −8.5 (−12.1 to −4.9) ** *** ***   NS
P3B −5.1 (−8.7 to −1.5) NS * ** NS  
Day 2       
AST Est (95% CI) PC P1 P2 P3A P3B
PC 286.0 (34.2 to 537.8)   NS NS *** NS
P1 362.9 (111.1 to 614.7) NS   NS *** NS
P2 96.8 (−155.0 to 348.6) NS NS   *** NS
P3A 1019.7 (767.9 to 1271.5) *** *** ***   ***
P3B 239.8 (−11.9 to 491.6) NS NS NS ***  
LDH Est (95% CI) PC P1 P2 P3A P3B
PC 217.8 (13.7 to 421.9)   NS NS NS NS
P1 137.8 (−66.3 to 341.9) NS   NS * NS
P2 33.9 (−170.2 to 238.0) NS NS   ** NS
P3A 430.1 (226.0 to 634.2) NS * **   **
P3B 72.2 (−131.9 to 276.3) NS NS NS **  
CK Est (95% CI) PC P1 P2 P3A P3B
PC 6.8 (3.3 to 13.8)   NS NS * NS
P1 8.6 (4.2 to 17.6) NS   * NS NS
P2 2.8 (1.4 to 5.8) NS *   *** NS
P3A 21.9 (10.7 to 44.8) * NS ***   ***
P3B 4.2 (2.0 to 8.5) NS NS NS ***  
Body Weight Est (95% CI) PC P1 P2 P3A P3B
PC 0.2 (−3.9 to 4.3)   NS NS NS NS
P1 1.9 (−2.2 to 6.0) NS   NS NS *
P2 2.1 (−2.0 to 6.2) NS NS   * *
P3A −2.4 (−6.5 to 1.7) NS NS *   NS
P3B −3.5 (−7.6 to 0.6) NS * * NS  
  1. PC control values, P1 protocol 1, P2 protocol 2, P3A protocol 3A, and P3B protocol 3B. Changes in AST, LDH and body weight are presented as day X – day 0 values; changes in CK are presented as fold increases day X/day 0 values (95% CI). The columns labelled PC, P1, P2, P3A and P3B summarise between treatment differences (NS = not significant, * < 0.05, ** < 0.01, *** < 0.001).
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