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Table 8 Estimated changes in muscle damage indicators (AST, LDH, and CK) and body weight one and two days after procedures

From: Comparison of three different sedative-anaesthetic protocols (ketamine, ketamine-medetomidine and alphaxalone) in common marmosets (Callithrix jacchus)

Day 1

      

AST

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

198.8 (8.5 to 389.1)

 

**

NS

***

NS

P1

526.0 (335.7 to 716.3)

**

 

***

***

*

P2

79.4 (−110.9 to 269.7)

NS

***

 

***

NS

P3A

1123.2 (932.9 to 1313.5)

***

***

***

 

***

P3B

246.4 (56.1 to 436.7)

NS

*

NS

***

 

LDH

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

78.5 (−119.6 to 276.6)

 

NS

NS

***

NS

P1

299.2 (101.1 to 497.3)

NS

 

NS

***

NS

P2

40.0 (−158.1 to 238.1)

NS

NS

 

***

NS

P3A

795.4 (597.3 to 993.5)

***

***

***

 

***

P3B

43.3 (−154.8 to 241.4)

NS

NS

NS

***

 

CK

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

7.2 (4.0 to 12.9)

 

***

NS

***

NS

P1

37.8 (21.1 to 67.7)

***

 

***

NS

**

P2

3.9 (2.2 to 7.0)

NS

***

 

***

*

P3A

74.2 (41.5 to 132.8)

***

NS

***

 

***

P3B

11.0 (6.2 to 19.7)

NS

**

*

***

 

Body Weight

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

−0.9 (−4.5 to 2.7)

 

NS

NS

**

NS

P1

0.5 (−3.1 to 4.1)

NS

 

NS

***

*

P2

1.8 (−1.8 to 5.4)

NS

NS

 

***

**

P3A

−8.5 (−12.1 to −4.9)

**

***

***

 

NS

P3B

−5.1 (−8.7 to −1.5)

NS

*

**

NS

 

Day 2

      

AST

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

286.0 (34.2 to 537.8)

 

NS

NS

***

NS

P1

362.9 (111.1 to 614.7)

NS

 

NS

***

NS

P2

96.8 (−155.0 to 348.6)

NS

NS

 

***

NS

P3A

1019.7 (767.9 to 1271.5)

***

***

***

 

***

P3B

239.8 (−11.9 to 491.6)

NS

NS

NS

***

 

LDH

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

217.8 (13.7 to 421.9)

 

NS

NS

NS

NS

P1

137.8 (−66.3 to 341.9)

NS

 

NS

*

NS

P2

33.9 (−170.2 to 238.0)

NS

NS

 

**

NS

P3A

430.1 (226.0 to 634.2)

NS

*

**

 

**

P3B

72.2 (−131.9 to 276.3)

NS

NS

NS

**

 

CK

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

6.8 (3.3 to 13.8)

 

NS

NS

*

NS

P1

8.6 (4.2 to 17.6)

NS

 

*

NS

NS

P2

2.8 (1.4 to 5.8)

NS

*

 

***

NS

P3A

21.9 (10.7 to 44.8)

*

NS

***

 

***

P3B

4.2 (2.0 to 8.5)

NS

NS

NS

***

 

Body Weight

Est (95% CI)

PC

P1

P2

P3A

P3B

PC

0.2 (−3.9 to 4.3)

 

NS

NS

NS

NS

P1

1.9 (−2.2 to 6.0)

NS

 

NS

NS

*

P2

2.1 (−2.0 to 6.2)

NS

NS

 

*

*

P3A

−2.4 (−6.5 to 1.7)

NS

NS

*

 

NS

P3B

−3.5 (−7.6 to 0.6)

NS

*

*

NS

 
  1. PC control values, P1 protocol 1, P2 protocol 2, P3A protocol 3A, and P3B protocol 3B. Changes in AST, LDH and body weight are presented as day X – day 0 values; changes in CK are presented as fold increases day X/day 0 values (95% CI). The columns labelled PC, P1, P2, P3A and P3B summarise between treatment differences (NS = not significant, * < 0.05, ** < 0.01, *** < 0.001).
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BMC Veterinary Research

ISSN: 1746-6148

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