Morphometric magnetic resonance imaging and genetic testing in cerebellar abiotrophy in Arabian horses

BMC Veterinary Research

Table 1 Patient data of 5 horses with histologically confirmed CA and comparative median values of MR morphometry of 15 control horses (controls)

	CA1	CA2	CA3	CA4	CA5	Controls
Signalment
Gender	Filly	Filly	Colt	Colt	Filly
Weight (kg)	212	232	244	294	104
Clinical details
Onset (months)	0	18	6	12	0
Age at examination (months)	19	42	19	13	2
Ataxia	+	-	+	+	+
Head tremor	+	+	+	-	+
Abnormal menace response	+	-	+	+	+
Clinical neuroanatomic location of lesion	Cerebellum	Cerebellum	Cerebellum	Cerebellum	Cerebellum
MR morphometry
Relative cerebellar size (%)	15.4	19.6	17.2	19.3	16.3	20.3 (18.8-22.7)
Relative cerebellar CSF space (%)	17.4	16.3	11.8	13.5	20.8	9.4 (6.2-13.3)
Pathology
Brain weight (g)	400	500	472	470	390
Weight (g) (isolated cerebellum)	27	47	37	48	25
Cerebellum: whole brain ratio (%)	6.75	9.4	7.8	10.2	6.41
Purkinje cell degeneration	+	+	+	+	+
Genetic testing
CA-associated TOE1 genotype	+	+	+	+	+
Conserved haplotype	+	+	+	+	+

ISSN: 1746-6148