Skip to main content

Table 1 Patient data of 5 horses with histologically confirmed CA and comparative median values of MR morphometry of 15 control horses (controls)

From: Morphometric magnetic resonance imaging and genetic testing in cerebellar abiotrophy in Arabian horses

  CA1 CA2 CA3 CA4 CA5 Controls
Signalment       
  Gender Filly Filly Colt Colt Filly  
  Weight (kg) 212 232 244 294 104  
Clinical details       
  Onset (months) 0 18 6 12 0  
  Age at examination (months) 19 42 19 13 2  
  Ataxia + - + + +  
  Head tremor + + + - +  
  Abnormal menace response + - + + +  
  Clinical neuroanatomic location of lesion Cerebellum Cerebellum Cerebellum Cerebellum Cerebellum  
MR morphometry       
  Relative cerebellar size (%) 15.4 19.6 17.2 19.3 16.3 20.3 (18.8-22.7)
  Relative cerebellar CSF space (%) 17.4 16.3 11.8 13.5 20.8 9.4 (6.2-13.3)
Pathology       
  Brain weight (g) 400 500 472 470 390  
  Weight (g) (isolated cerebellum) 27 47 37 48 25  
  Cerebellum: whole brain ratio (%) 6.75 9.4 7.8 10.2 6.41  
  Purkinje cell degeneration + + + + +  
Genetic testing       
CA-associated TOE1 genotype + + + + +  
Conserved haplotype + + + + +  
  1. CA - cerebellar abiotrophy.
  2. MRI - magnetic resonance imaging.
  3. CSF - cerebrospinal fluid.
  4. Values in parenthesis show the range of calculated ratios for the controls.