Figure 3

Ingenuity pathway analysis of some key proteins identified in the study. Each gene involved in the pathway is denoted by their ENTREZ gene symbol or in some cases full gene name. The proteins indicated in red circles showed statistically significant (p < 0.05) differential expression and/ or fold change >1.5 in comparative 2D gel analysis. Grey circles indicate other proteins involved in the pathway. Different coloured arrows are shown to highlight the central molecules involved in the pathway namely; CD3, JNK, ERK1, LDL and APOA. Solid arrows indicate direct protein interactions and dashed arrows indicate indirect protein interactions. Pathway analysis was done based on the mammalian orthologs of the proteins identified in cod mucus.