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Table 4 Prognostic factors significantly associated with disease free survival

From: Identification of prognostic factors in canine mammary malignant tumours: a multivariable survival study

Variable Univariate Multivariable*
  Hazard ratio 95% CI P Hazard ratio 95% CI P
Tumour size       
< 3 cm Referent      
≥ 3 cm 2.33 1.06-5.14 0.036    NS
Mode of growth       
Expansive Referent      
Invasive 5.62 1.33-23.80 0.019    NS
MIB1 L.I. (%)       
< 40 Referent    Referent   
≥ 40 4.15 1.74-9.90 0.001 3.24 1.35-7.78 0.009
uPA (%)       
< 10 Referent      
≥ 10 3.82 1.14-12.72 0.029    NS
MMP-9 (%)       
< 50 Referent    Referent   
≥ 50 4.34 1.93-9.77 <0.001 3.38 1.49-7.67 0.004
  1. *Cox regression model: forward stepwise method – likelihood ratio.
  2. NS - not significant.