Bioavailability and pharmacokinetics of oral meloxicam in llamas

BMC Veterinary Research

Table 5 Comparison of pharmacokinetic parameters of meloxicam in domestic animal species, IV administration

	IV administration (mean values)
Parameter	Llamas*	Cattle*	Goats*	Horses^**	Sheep*	Camels*
(Units)	(present study)	[18]	[19]	[20]	[21]	[22]
AUC _INF *(hrμg/mL)**	43.96	82.34	29.74	NR	49.26	346.7
Cl or Cl _T (mL/min/kg)	0.190	0.1	0.298	0.34	0.169	0.032
C0 (μg/mL)	6.16	5.93	3.12	NR	4.96	NR
T ½ λz or T ½ _β (hr)	17.4	20.35	10.9	8.54	14.0	40.2
Vss (L/kg)	0.235	0.171	0.245	0.12	178.7	0.093
Dose (mg/kg)	0.5	0.5	0.5	0.6	0.5	0.6

NR = not reported.
* Non-compartmental pharmacokinetic analysis.
** Compartmental pharmacokinetic analysis.
AUC_INF = area under the curve extrapolated to infinity; Cl = plasma clearance; Cl_T = total body clearance; C0 = Concentration extrapolated to time 0 using log-linear regression of the first two time points; T ½ λz, T ½ _β = terminal half-life; Vss = volume of distribution at steady state.

ISSN: 1746-6148