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Table 4 Comparison of pharmacokinetic parameters of meloxicam in domestic animal species, PO administration

From: Bioavailability and pharmacokinetics of oral meloxicam in llamas

 

PO administration (mean values)

Parameter

Llamas*

Cattle*

Goats*

Horses**

Sheep*

(Units)

(present study)

[18]

[19]

[20]

[21]

AUC INF (hr*μg/mL)

68.35

164.46

23.24

NR

75.09

Cl/F (mL/min/kg)

0.248

0.1

NR

NR

0.220

C MAX (μg/mL)

1.31

3.10

0.736

1.73

1.715

T MAX (hr)

21.4

11.64

15

3.4

19.0

T ½ λz (hr)

22.7

27.54

11.8

NR

15.4

Vz/F (L/kg)

0.487

0.242

NR

NR

0.293

Dose (mg/kg)

1.0

1.0

0.5

0.6

0.99

F (%)

76.0

100.0

79.0

95.6

72.0

  1. NR = not reported.
  2. * Non-compartmental pharmacokinetic analysis.
  3. ** Compartmental pharmacokinetic analysis.
  4. AUCINF = area under the curve extrapolated to infinity; Cl/F = Cl per fraction of the dose absorbed; CMAX = maximum plasma concentration; TMAX; = time to CMAX; T ½ λz, T ½β = terminal half-life; Vz/F = Vz per fraction of the dose absorbed; F = fraction of the dose absorbed.
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BMC Veterinary Research

ISSN: 1746-6148

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