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Table 1 Meloxicam pharmacokinetic parameters following a single IV (0.5 mg/kg) or PO (1.0 mg/kg) administration

From: Bioavailability and pharmacokinetics of oral meloxicam in llamas

 

IV

PO

Parameter (Units)

Geometric Mean

Min

Median

Max

Geometric Mean

Min

Median

Max

AUC extrapolated (%)

1.9

1.4

1.7

3.5

6.6

3.6

6.3

13.1

AUC INF (hr*μg/mL)

43.96

31.44

43.45

55.60

68.35

52.37

74.98

79.24

Cl (mL/min/kg)

0.190

0.151

0.192

0.260

N/A

N/A

N/A

N/A

Cl/F (mL/min/kg)

N/A

N/A

N/A

N/A

0.248

0.212

0.230

0.318

C0 (μg/mL)

6.163

5.257

5.930

7.631

N/A

N/A

N/A

N/A

C MAX (μg/mL)

N/A

N/A

N/A

N/A

1.314

.826

1.368

1.776

T MAX (hr)

N/A

N/A

N/A

N/A

21.4

12.0

24.0

24.0

T ½ λz (hr)

17.4

16.2

16.8

20.7

22.7

18.0

21.9

30.8

λz (1/hr)

0.0398

0.0335

0.0413

0.0428

0.0306

0.0225

0.0316

0.0386

MRT (hr)

20.6

17.7

20.0

26.5

41.7

35.4

40.7

51.3

Vss (L/kg)

0.235

0.206

0.237

0.282

N/A

N/A

N/A

N/A

Vz (L/kg)

0.286

0.213

0.293

0.365

N/A

N/A

N/A

N/A

Vz/F (L/kg)

N/A

N/A

N/A

N/A

0.487

0.331

0.464

0.748

Dose (mg/kg)

0.50

0.49

0.50

0.51

1.0

1.0

1.0

1.1

MAT (hr)

N/A

N/A

N/A

N/A

20.8

13.9

22.6

24.8

F

N/A

N/A

N/A

N/A

0.76

0.48

0.85

0.92

  1. Meloxicam noncompartmental pharmacokinetics (WinNonlin 5.2, Pharsight Inc. Cary NC, USA).
  2. AUC extrapolated = percent of the AUC extrapolated; AUCINF = area under the curve extrapolated to infinity; Cl = plasma clearance; Cl/F = Cl per fraction of the dose absorbed; C0 = Concentration extrapolated to time 0 using log-linear regression of the first two time points; TMAX = time to CMAX; T ½ λz = terminal half-life; λz = terminal rate constant; MRT = mean residence time extrapolated to infinity; Vss = volume of distribution at steady state; Vz = volume of distribution, area method; Vz/F = Vz per fraction of the dose absorbed; MAT = mean absorption time; F = fraction of the dose absorbed.
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BMC Veterinary Research

ISSN: 1746-6148

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