Treatment | Day | ||||
---|---|---|---|---|---|
0 | 21 | 42 | 60 | 90 | |
I. Control | 123 ± 10 | 132 ± 12 | 127 ± 12 | 131 ± 8 | 126 ± 10 |
II. Melatonin Implant | 125 ± 10 | 277 ± 14*† | 296 ± 15*† | 292 ± 12*† | 261 ± 10 |
III. Vaccine | 120 ± 14 | 126 ± 10 | 124 ± 12 | 128 ± 12 | 130 ± 10 |
IV. Vaccine+Melatonin Implant | 126 ± 12 | 295 ± 11*† | 328 ± 13*† | 313 ± 9*† | 287 ± 14*† |