|
Treatment
| | |
Day
| | |
|---|
|
0
|
21
|
42
|
60
|
90
|
|---|
|
I. Control
|
123 ± 10
|
132 ± 12
|
127 ± 12
|
131 ± 8
|
126 ± 10
|
|
II. Melatonin Implant
|
125 ± 10
|
277 ± 14*†
|
296 ± 15*†
|
292 ± 12*†
|
261 ± 10
|
|
III. Vaccine
|
120 ± 14
|
126 ± 10
|
124 ± 12
|
128 ± 12
|
130 ± 10
|
|
IV. Vaccine+Melatonin Implant
|
126 ± 12
|
295 ± 11*†
|
328 ± 13*†
|
313 ± 9*†
|
287 ± 14*†
|
- Values represent mean melatonin concentration as determined by enzyme-linked immunosorbent assay (ELISA). Data are expressed as pg/mL and presented as mean ± S.E.M. of 10 experiments. *P < 0.05 compared with day 0. †P < 0.05 compared with their respective control in non-vaccinated animals.
