PHARMACOKINETIC PARAMETERS | FLBZ | R-FLBZ | ||
---|---|---|---|---|
FLBZ-CDs i.r. treatment | FLBZ-CMC i.r. treatment | FLBZ-CDs i.r. treatment | FLBZ-CMC i.r. treatment | |
Cmax (μg/mL) | 0.11 ± 0.01 | 0.16 ± 0.06 | 0.43 ± 0.13 | 0.67 ± 0.40* |
Tmax (h) | 10.5 ± 3.00 | 9.75 ± 2.87 | 12.8 ± 3.77 | 12.0 ± 0.00 |
AUC0-t (μg.h/mL) | 2.95 ± 0.66 | 3.63 ± 1.05 | 12.0 ± 5.01 | 21.7 ± 15.8 |
T½el (h) | 12.3 ± 5.99 | 9.83 ± 4.23 | 16.2 ± 7.54 | 16.3 ± 5.95 |
MRT (h) | 23.0 ± 8.28 | 20.4 ± 5.23 | 30.0 ± 12.1 | 31.2 ± 8.80 |