TY - JOUR AU - Kateregga, John AU - Lubega, George W. AU - Lindblad, Erik B. AU - Authié, Edith AU - Coetzer, Theresa Helen Taillefer AU - Boulangé, Alain François Vincent PY - 2012 DA - 2012/05/23 TI - Effect of adjuvants on the humoral immune response to congopain in mice and cattle JO - BMC Veterinary Research SP - 63 VL - 8 IS - 1 AB - We investigated several adjuvants for their effects on the humoral immune response in both mice and cattle using the central domain of congopain (C2), the major cysteine protease of Trypanosoma congolense, as a model for developing a vaccine against animal trypanosomosis. The magnitude and sustainability of the immune response against C2 and the occurrence of a booster effect of infection, an indirect measure of the presence of memory cells, were determined by ELISA, while spectrofluorometry was used to determine and measure the presence of enzyme-inhibiting antibodies. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-63 DO - 10.1186/1746-6148-8-63 ID - Kateregga2012 ER -