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Table 5 Responses of pigs to vaccination with O/HN/CHA/93 and rM-HN vaccines and O/Tibet/CHA/99 challenge

From: Evaluation of a genetically modified foot-and-mouth disease virus vaccine candidate generated by reverse genetics

Vaccinea

Pig no.

VNT titer versus O/Tibet/CHA/99b

Response to challenge with O/Tibet/CHA/99

Vaccinea

Pig no.

VNT titer versus O/Tibet/CHA/99b

Response to challenge with O/Tibet/CHA/99

Lesionsc

3ABCd

Lesionsc

3ABCd

O/HN/CHA/93

101

1.6

-

-

rM-HN

601

2.1

-

-

102

1.7

-

-

202

1.6

-

-

103

2.0

-

-

203

1.6

-

-

104

1.7

-

-

204

2.0

-

-

105

1.5

-

-

205

1.8

-

-

106

2.1

-

-

206

2.1

-

-

107

1.8

-

-

207

1.7

-

-

108

2.0

-

-

208

1.9

-

-

109

1.5

-

-

209

1.8

-

-

110

1.9

-

-

210

2.0

-

-

111

2.1

-

-

211

1.8

-

+

112

1.9

-

-

212

2.0

-

-

113

1.8

-

-

213

1.6

-

-

114

1.6

-

-

214

2.1

-

-

115

2.1

-

-

215

1.7

-

-

116

1.7

-

-

216

2.0

-

-

Control

117

<1.0

++

+

Control

217

<1.0

++

+

 

118

<1.0

++

+

 

218

<1.0

++

+

  1. a BEI-inactivated virus.
  2. b Day 28 virus neutralization titer (expressed as the log10 of the reciprocal antibody dilution required for 50% neutralization of 100 TCID50 virus) values represent the means from two repeat tests.
  3. c Scoring of clinical signs: -, no visible lesions, +, localized gross lesions; + +, generalized lesions.
  4. d Presence of antibodies to the nonstructural protein 3ABC in sera collected 14 days post-challenge, determined by the commercially available 3ABC-I-ELISA kit. Samples were considered positive if the cutoff value ≥0.2.