Table 1 Dose-dependent effect of SNP with/without inhibitors on bcl-2 protein level in canine CCL and CaCL cells

Control

6.6 ± 0.3

7.0 ± 0.4

SNP (0.3 mM)

6.5 ± 0.1

5.1 ± 0.3*

SNP (0.5 mM)

5.5 ± 0.3*

4.9 ± 0.2*

SNP (1 mM)

2.8 ± 0.2**

3.9 ± 0.1**

SNP (0.5 mM) + Genistein (50 μM)

8.8 ± 0.2††

10.9 ± 0.4††

SNP (0.5 mM) + Uric acid (0.5 mM)

7.8 ± 0.1††

7.9 ± 0.1††

SNP (0.5 mM) + Taxifolin (50 μM)

7.6 ± 0.3†

6.7 ± 0.4†

SNP (0.5 mM) + PTIO (5 μM)

5.8 ± 0.2

5.1 ± 0.2