TY - JOUR AU - Forterre, Simone AU - Zurbriggen, Andreas AU - Spreng, David PY - 2012 DA - 2012/03/29 TI - Nitric oxide induces cell death in canine cruciate ligament cells by activation of tyrosine kinase and reactive oxygen species JO - BMC Veterinary Research SP - 40 VL - 8 IS - 1 AB - There is increasing evidence suggesting that development of progressive canine cranial cruciate ligament (CCL) rupture involves a gradual degeneration of the CCL itself, initiated by a combination of factors, ranging from mechanical to biochemical. To date, knowledge is lacking to what extent cruciate disease results from abnormal biomechanics on a normal ligament or contrary how far preliminary alterations of the ligament due to biochemical factors provoke abnormal biomechanics. This study is focused on nitric oxide (NO), one of the potential biochemical factors. The NO-donor sodium nitroprusside (SNP) has been used to study NO-dependent cell death in canine cranial and caudal cruciate ligament cells and to characterize signaling mechanisms during NO-stimulation. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-40 DO - 10.1186/1746-6148-8-40 ID - Forterre2012 ER -