Serum protein profiles as potential biomarkers for infectious disease status in pigs

BMC Veterinary Research

Table 1 Overview of the statistical analyses (A-H) with the accompanying data sets that were used

	Analysis			Day 5 p.i.			Day 19 p.i.
2/3way	comparison	Day p.i.	Control	PCV2/ PPV	PCV2/ PRRSV	Control	PCV2/ PPV	PCV2/ PRRSV
2-way	Infected (A2) versus non-infected (A1)	5, 19	A1^a	A2	A2	A1	A2	A2
	PCV2/PPV versus control	5	B1	B2
	PCV2/PRRSV versus control	5	C1		C2
	PCV2/PPV versus control	19				D1	D2
	PCV2/PRRSV versus control	19				E1		E2
	PCV2/PPV versus control	5, 19	F1	F2		F1	F2
	PCV2/PRRSV versus control	5, 19	G1		G2	G1		G2
3-way	PCV2/PPV, PCV2/PRRSV, control	5, 19	H1	H2	H3	H1	H2	H3

^a Serum protein profiles of animals in groups with the same code have been clustered for statistical analysis.
Different comparisons (A-H) were carried out, including serum protein profiles of animals from different infection groups and/or time points after infection. SELDI-TOF-MS profiles were obtained from three week old piglets that were experimentally infected with either a combination of PCV2 and PRRSV (PCV2/PRRSV), PCV2 and PPV (PCV2/PPV), or phosphate buffered saline (controls). Statistical analyses were based on data from day five post infection (p.i.), day 19 p.i., or data from both days combined as indicated in the table.

ISSN: 1746-6148