TY - JOUR AU - Koene, Miriam GJ AU - Mulder, Han A. AU - Stockhofe-Zurwieden, Norbert AU - Kruijt, Leo AU - Smits, Mari A. PY - 2012 DA - 2012/03/22 TI - Serum protein profiles as potential biomarkers for infectious disease status in pigs JO - BMC Veterinary Research SP - 32 VL - 8 IS - 1 AB - In veterinary medicine and animal husbandry, there is a need for tools allowing the early warning of diseases. Preferably, tests should be available that warn farmers and veterinarians during the incubation periods of disease and before the onset of clinical signs. The objective of this study was to explore the potential of serum protein profiles as an early biomarker for infectious disease status. Serum samples were obtained from an experimental pig model for porcine circovirus-associated disease (PCVAD), consisting of Porcine Circovirus type 2 (PCV2) infection in combination with either Porcine Parvovirus (PPV) or Porcine Reproductive and Respiratory Syndrome virus (PRRSV). Sera were collected before and after onset of clinical signs at day 0, 5 and 19 post infection. Serum protein profiles were evaluated against sera from non-infected control animals. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-32 DO - 10.1186/1746-6148-8-32 ID - Koene2012 ER -