TY - JOUR AU - Strazzullo, Maria AU - Corteggio, Annunziata AU - Altamura, Gennaro AU - Francioso, Romina AU - Roperto, Franco AU - D'Esposito, Maurizio AU - Borzacchiello, Giuseppe PY - 2012 DA - 2012/03/16 TI - Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids JO - BMC Veterinary Research SP - 30 VL - 8 IS - 1 AB - Sarcoids are peculiar equine benign tumours. Their onset is associated with Bovine Papillomavirus type -1 or -2 (BPV-1/2) infection. Little is known about the molecular interplay between viral infection and neoplastic transformation. The data regarding papillomavirus infections in human species show the inactivation of a number of tumour suppressor genes as basic mechanism of transformation. In this study the putative role of the tumour suppressor gene Fragile Histidine Triad (FHIT) in sarcoid tumour was investigated in different experimental models. The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissue. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-30 DO - 10.1186/1746-6148-8-30 ID - Strazzullo2012 ER -