TY - JOUR AU - Ferrari, Angelo AU - Petterino, Claudio AU - Ratto, Alessandra AU - Campanella, Chiara AU - Wurth, Roberto AU - Thellung, Stefano AU - Vito, Guendalina AU - Barbieri, Federica AU - Florio, Tullio PY - 2012 DA - 2012/03/14 TI - CXCR4 expression in feline mammary carcinoma cells: evidence of a proliferative role for the SDF-1/CXCR4 axis JO - BMC Veterinary Research SP - 27 VL - 8 IS - 1 AB - Mammary tumours frequently develop in female domestic cats being highly malignant in a large percentage of cases. Chemokines regulate many physiological and pathological processes including organogenesis, chemotaxis of inflammatory cells, as well as tumour progression and metastasization. In particular, the chemokine/receptor pair SDF-1/CXCR4 has been involved in the regulation of metastatic potential of neoplastic cells, including breast cancer. The aim of this study was the immunohistochemical defininition of the expression profile of CXCR4 in primary and metastatic feline mammary carcinomas and the evaluation of the role of SDF-1 in feline mammary tumour cell proliferation. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-27 DO - 10.1186/1746-6148-8-27 ID - Ferrari2012 ER -