TY - JOUR AU - Couto, Jason I. AU - Bear, Misty D. AU - Lin, Jiayuh AU - Pennel, Michael AU - Kulp, Samuel K. AU - Kisseberth, William C. AU - London, Cheryl A. PY - 2012 DA - 2012/12/17 TI - Biologic activity of the novel small molecule STAT3 inhibitor LLL12 against canine osteosarcoma cell lines JO - BMC Veterinary Research SP - 244 VL - 8 IS - 1 AB - STAT3 [1] has been shown to be dysregulated in nearly every major cancer, including osteosarcoma (OS). Constitutive activation of STAT3, via aberrant phosphorylation, leads to proliferation, cell survival and resistance to apoptosis. The present study sought to characterize the biologic activity of a novel allosteric STAT3 inhibitor, LLL12, in canine OS cell lines. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-244 DO - 10.1186/1746-6148-8-244 ID - Couto2012 ER -