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Table 4 Blood concentrations of selected laboratory parameters in different treatment groups on admission and at the end of the study period

From: Construction and validation of a decision tree for treating metabolic acidosis in calves with neonatal diarrhea

  

Group I:

Group II:

Group III:

Group IV:

Group V:

Oral rehydration

Constant drip infusion

Short-term infusion

Constant drip infusion

Constant drip infusion

250 mmol NaHCO3

500/750 mmol NaHCO3

500 mmol NaHCO3

750 mmol NaHCO3

n = 20

n = 47

n = 10

n = 34/29 (0 h/24 h)

n = 10

Base Excess (mmol/l)

0 h

2.8 (−5.3/7.4)III, IV, V

0.0 (−8.8/4.2)III, IV, V

−17.2 (−19.9/-9.7)I, II

−18.9 (−22.7/-14.5) I, II

−22.9 (−25.1/-19.0) I, II

24 h

4.5 (0.8/8.5)

5.3 (1.8/7.9)

3.1 (−4.1/5.6)

2.1 (−1.2/8.0)

7.8 (3.7/11.2)

D-Lactate (mmol/l)

0 h

0.9 (0.2/5.6)III, IV

0.8 (0.5/2.4)III, IV, V

11.7 (8.7/12.9)I, II, IV

7.0 (1.9/10.8)I, II, III

6.4 (2.1/12.0)II

24 h

0.5 (0.2/2.6)III

0.3 (0.1/0.9)III, IV, V

4.5 (2.7/6.8)I, II

1.3 (0.3/4.6)II

1.5 (0.7/4.6)II

L-Lactate (mmol/l)

0 h

1.1 (0.7/2.0)II

2.7 (1.4/4.1)I, III

0.6 (0.4/0.6)II, IV, V

2.7 (0.9/5.9)III

2.6 (0.8/6.0)III

24 h

1.2 (0.9/2.2)

1.5 (1.1/2.1)III

0.9 (0.7/1.2)II, V

1.4 (1.0/2.1)

1.6 (1.0/3.0)III

Total protein (g/l)

0 h

53.6 (46.5/56.8)IV, V

58.2 (51.9/66.0)V

50.9 (48.7/59.8)IV, V

64.5 (57.1/74.8)I, III

72.4 (63.4/80.4)I, II, III

24 h

50.8 (43.8/55.0)

49.6 (43.6/53.8)

46.2 (43.9/51.4)

48.0 (43.0/54.5)

47.4 (43.2/58.6)

Urea (mmol/l)

0 h

6.0 (3.3/8.3)II, IV, V

13.0 (6.7/20.4)I, IV; V

8.4 (6.9/10.9)IV, V

17.9 (15.2/26.9)I, II, III

29.2 (19.6/34.1)I, II, III

24 h

4.7 (3.0/7.7)IV, V

5.0 (3.8/9.4)

4.7 (3.7/5.7)IV, V

8.3 (5.2/13.7)I, III

11.9 (9.5/19.2)I, III

Creatinine (μmol/l)

0 h

100.6 (76.0/124.6)IV, V

130.8 (87.7/271.9)IV, V

95.1 (73.1/134.4)IV, V

262.9 (148.4/433.5)I, II, III

411.1 (188.3/623.3)I, II, III

24 h

81.3 (72.6/128.9)

80.7 (63.6/120.2)

72.1 (66.5/88.2)

98.1 (70.4/207.5)

112.3 (81.3/252.4)

Potassium (mmol/l)

0 h

4.5 (4.1/4.9)II, IV, V

5.1 (4.5/6.0)I, III, V

4.1 (3.9/4.5)II, IV, V

6.0 (4.4/7.3)I, III

8.1 (5.6/8.5)I, II, III

24 h

4.7 (4.4/5.1)IV

4.6 (4.3/5.0)

4.4 (3.5/4.8)

4.3 (3.8/4.5)I

4.5 (3.5/5.0)

Sodium (mmol/l)

0 h

134.0 (129.9/135.8)

133.2 (129.3/137.2)

136.0 (133.9/137.6)

135.4 (130.2/143.3)

128.4 (115.7/144.1)

24 h

133.2 (131.6/137.9)

135.2 (133.1/137.8)

133.0 (131.9/136.4)

137.1 (134.4/143.8)

138.9 (135.3/145.4)

Anion gap (mEq/l)

0 h

12.3 (8.7/17.1)III, IV, V

16.6 (12.8/22.7)III, IV, V

24.2 (21.4/28.2)I, II, IV, V

28.2 (26.4/34.6)I, II, III

31.9 (29.8/36.9)I, II, III

 

24 h

11.4 (7.4/14.0)

9.7 (7.2/12.3)

11.5 (9.1/16.5)

12.5 (9.6/14.8)

12.6 (8.5/18.0)

  1. Values are given as medians and 25-/75-quartiles. Superscripts indicate number of groups with significantly different values after pairwise comparisons. Bold median values indicate statistically significant changes during the investigation period. Five out of 34 calves of treatment group IV had to be treated alternatively for reasons of expected treatment failure. Comparisons between times of examination were performed for the remaining 29 calves of this group.