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Table 4 Blood concentrations of selected laboratory parameters in different treatment groups on admission and at the end of the study period

From: Construction and validation of a decision tree for treating metabolic acidosis in calves with neonatal diarrhea

   Group I: Group II: Group III: Group IV: Group V:
Oral rehydration Constant drip infusion Short-term infusion Constant drip infusion Constant drip infusion
250 mmol NaHCO3 500/750 mmol NaHCO3 500 mmol NaHCO3 750 mmol NaHCO3
n = 20 n = 47 n = 10 n = 34/29 (0 h/24 h) n = 10
Base Excess (mmol/l) 0 h 2.8 (−5.3/7.4)III, IV, V 0.0 (−8.8/4.2)III, IV, V −17.2 (−19.9/-9.7)I, II −18.9 (−22.7/-14.5) I, II −22.9 (−25.1/-19.0) I, II
24 h 4.5 (0.8/8.5) 5.3 (1.8/7.9) 3.1 (−4.1/5.6) 2.1 (−1.2/8.0) 7.8 (3.7/11.2)
D-Lactate (mmol/l) 0 h 0.9 (0.2/5.6)III, IV 0.8 (0.5/2.4)III, IV, V 11.7 (8.7/12.9)I, II, IV 7.0 (1.9/10.8)I, II, III 6.4 (2.1/12.0)II
24 h 0.5 (0.2/2.6)III 0.3 (0.1/0.9)III, IV, V 4.5 (2.7/6.8)I, II 1.3 (0.3/4.6)II 1.5 (0.7/4.6)II
L-Lactate (mmol/l) 0 h 1.1 (0.7/2.0)II 2.7 (1.4/4.1)I, III 0.6 (0.4/0.6)II, IV, V 2.7 (0.9/5.9)III 2.6 (0.8/6.0)III
24 h 1.2 (0.9/2.2) 1.5 (1.1/2.1)III 0.9 (0.7/1.2)II, V 1.4 (1.0/2.1) 1.6 (1.0/3.0)III
Total protein (g/l) 0 h 53.6 (46.5/56.8)IV, V 58.2 (51.9/66.0)V 50.9 (48.7/59.8)IV, V 64.5 (57.1/74.8)I, III 72.4 (63.4/80.4)I, II, III
24 h 50.8 (43.8/55.0) 49.6 (43.6/53.8) 46.2 (43.9/51.4) 48.0 (43.0/54.5) 47.4 (43.2/58.6)
Urea (mmol/l) 0 h 6.0 (3.3/8.3)II, IV, V 13.0 (6.7/20.4)I, IV; V 8.4 (6.9/10.9)IV, V 17.9 (15.2/26.9)I, II, III 29.2 (19.6/34.1)I, II, III
24 h 4.7 (3.0/7.7)IV, V 5.0 (3.8/9.4) 4.7 (3.7/5.7)IV, V 8.3 (5.2/13.7)I, III 11.9 (9.5/19.2)I, III
Creatinine (μmol/l) 0 h 100.6 (76.0/124.6)IV, V 130.8 (87.7/271.9)IV, V 95.1 (73.1/134.4)IV, V 262.9 (148.4/433.5)I, II, III 411.1 (188.3/623.3)I, II, III
24 h 81.3 (72.6/128.9) 80.7 (63.6/120.2) 72.1 (66.5/88.2) 98.1 (70.4/207.5) 112.3 (81.3/252.4)
Potassium (mmol/l) 0 h 4.5 (4.1/4.9)II, IV, V 5.1 (4.5/6.0)I, III, V 4.1 (3.9/4.5)II, IV, V 6.0 (4.4/7.3)I, III 8.1 (5.6/8.5)I, II, III
24 h 4.7 (4.4/5.1)IV 4.6 (4.3/5.0) 4.4 (3.5/4.8) 4.3 (3.8/4.5)I 4.5 (3.5/5.0)
Sodium (mmol/l) 0 h 134.0 (129.9/135.8) 133.2 (129.3/137.2) 136.0 (133.9/137.6) 135.4 (130.2/143.3) 128.4 (115.7/144.1)
24 h 133.2 (131.6/137.9) 135.2 (133.1/137.8) 133.0 (131.9/136.4) 137.1 (134.4/143.8) 138.9 (135.3/145.4)
Anion gap (mEq/l) 0 h 12.3 (8.7/17.1)III, IV, V 16.6 (12.8/22.7)III, IV, V 24.2 (21.4/28.2)I, II, IV, V 28.2 (26.4/34.6)I, II, III 31.9 (29.8/36.9)I, II, III
  24 h 11.4 (7.4/14.0) 9.7 (7.2/12.3) 11.5 (9.1/16.5) 12.5 (9.6/14.8) 12.6 (8.5/18.0)
  1. Values are given as medians and 25-/75-quartiles. Superscripts indicate number of groups with significantly different values after pairwise comparisons. Bold median values indicate statistically significant changes during the investigation period. Five out of 34 calves of treatment group IV had to be treated alternatively for reasons of expected treatment failure. Comparisons between times of examination were performed for the remaining 29 calves of this group.