Subjects | Intradermal challenge | Drug | Administration route | Treatment time | Wheal inhibition vs baseline | Ref |
---|---|---|---|---|---|---|
Healthy Beagle dogs | Anti-canine IgE | Corticosteroids (prednisolone) | Oral | Twice daily for 3 days | No effect | [38] |
Dogs with pruritic dermatitis | Histamine (5 different dilutions) | Corticosteroids (hydrocortisone 1%) | Topical (conditioner) | Twice weekly for 6 weeks | No effect | [39] |
Healthy Beagle dogs | Histamine | Corticosteroids (betamethasone) | Topical (otic preparation) | Twice daily for 2 weeks | 5.9% | [40] |
Healthy Beagle dogs | D. farinae | Corticosteroids (betamethasone) | Topical (otic preparation) | Twice daily for 2 weeks | 9% | [40] |
Healthy Beagle dogs | Cynodon dactylon | Corticosteroids (betamethasone) | Topical (otic preparation) | Twice daily for 2 weeks | 9.8% | [40] |
Healthy Beagle dogs | Anti-canine IgE | Corticosteroids (hydrocortisone 1%) | Topical (conditioner) | 3 days | 14% (*) | [41] |
Healthy dogs | Anti-canine IgE (different dilutions) | Corticosteroids (triamcinolone) | Topical (solution) | 7 days | 24-45% (§) depending on the stimulus concentration | [42] |
Healthy mixed breed dogs | D. farinae | Corticosteroids (prednisone) | Oral | 7 days | 41% | [43] |
Atopic Maltese-beagle cross-breed dogs | Anti-canine IgE | Corticosteroids (hydrocortisone aceponate) | Topical (spray) | 7 days | 72% | [44] |
Healthy mixed breed dogs | D. farinae | Antihistamines (cetrizine) | Oral | 14 days | 49% | [43] |
Spontaneously Ascaris hypersensitive Beagle dogs | A. suum | Antihistamines (rupatadine) | Oral | Single pre-treatment dose | 35, 67 and 84% (#) | [27] |
Spontaneously Ascaris hypersensitive Beagle dogs | A. suum | Antihistamines (loratadine) | Oral | Single pre-treatment dose | 34, 61 and 66% (#) | [27] |
Healthy Beagle dogs | PAF | Antihistamines (rupatadine) | Oral | Single pre-treatment dose | 30% to 45% (Â¥) | [47] |
Healthy Beagle dogs | Histamine | Antihistamines (rupatadine) | Oral | Single pre-treatment dose | 50% to 80% (Â¥) | [47] |
Healthy Beagle dogs | Histamine | Antihistamines (cetrizine, loratadine, rupatadine, levocabastine) | Oral | Single pre-treatment dose | 70% to 80% (**) | [48] |
Healthy Beagle dogs | Histamine | Antihistamines (cetrizine, loratadine, rupatadine, levocabastine) | Oral | Single pre-treatment dose | 70% to 80% (**) | [48] |