Skip to main content

Table 2 Main studies on the inhibition of skin wheal response in dogs - key findings

From: Inhibitory effect of topical Adelmidrol on antigen-induced skin wheal and mast cell behavior in a canine model of allergic dermatitis

Subjects

Intradermal challenge

Drug

Administration route

Treatment time

Wheal inhibition vs baseline

Ref

Healthy Beagle dogs

Anti-canine IgE

Corticosteroids (prednisolone)

Oral

Twice daily for 3 days

No effect

[38]

Dogs with pruritic dermatitis

Histamine (5 different dilutions)

Corticosteroids (hydrocortisone 1%)

Topical (conditioner)

Twice weekly for 6 weeks

No effect

[39]

Healthy Beagle dogs

Histamine

Corticosteroids (betamethasone)

Topical (otic preparation)

Twice daily for 2 weeks

5.9%

[40]

Healthy Beagle dogs

D. farinae

Corticosteroids (betamethasone)

Topical (otic preparation)

Twice daily for 2 weeks

9%

[40]

Healthy Beagle dogs

Cynodon dactylon

Corticosteroids (betamethasone)

Topical (otic preparation)

Twice daily for 2 weeks

9.8%

[40]

Healthy Beagle dogs

Anti-canine IgE

Corticosteroids (hydrocortisone 1%)

Topical (conditioner)

3 days

14% (*)

[41]

Healthy dogs

Anti-canine IgE (different dilutions)

Corticosteroids (triamcinolone)

Topical (solution)

7 days

24-45% (§) depending on the stimulus concentration

[42]

Healthy mixed breed dogs

D. farinae

Corticosteroids (prednisone)

Oral

7 days

41%

[43]

Atopic Maltese-beagle cross-breed dogs

Anti-canine IgE

Corticosteroids (hydrocortisone aceponate)

Topical (spray)

7 days

72%

[44]

Healthy mixed breed dogs

D. farinae

Antihistamines (cetrizine)

Oral

14 days

49%

[43]

Spontaneously Ascaris hypersensitive Beagle dogs

A. suum

Antihistamines (rupatadine)

Oral

Single pre-treatment dose

35, 67 and 84% (#)

[27]

Spontaneously Ascaris hypersensitive Beagle dogs

A. suum

Antihistamines (loratadine)

Oral

Single pre-treatment dose

34, 61 and 66% (#)

[27]

Healthy Beagle dogs

PAF

Antihistamines (rupatadine)

Oral

Single pre-treatment dose

30% to 45% (Â¥)

[47]

Healthy Beagle dogs

Histamine

Antihistamines (rupatadine)

Oral

Single pre-treatment dose

50% to 80% (Â¥)

[47]

Healthy Beagle dogs

Histamine

Antihistamines (cetrizine, loratadine, rupatadine, levocabastine)

Oral

Single pre-treatment dose

70% to 80% (**)

[48]

Healthy Beagle dogs

Histamine

Antihistamines (cetrizine, loratadine, rupatadine, levocabastine)

Oral

Single pre-treatment dose

70% to 80% (**)

[48]

  1. (*) versus placebo group;
  2. (§) versus vehicle-treated side;
  3. (#) peak activity at 0.1, 1 and 10 mg/Kg respectively, 2 to 4 hrs after administration;
  4. (Â¥) peak activity, 4 h after administration, depending on the dose;
  5. (**) peak activity, 4 h after administration, depending on the compound and the dose.