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Table 4 Amplification of experimental and natural strains of ovine prion diseases

From: In vitro amplification of ovine prions from scrapie-infected sheep from Great Britain reveals distinct patterns of propagation

Strain

Genotype

Substrate

VRQ

ARQ

AFRQ*

SSBP1 (n = 1)

VRQ

+

-

ND

Dawson (n = 1)

VRQ

+

-

ND

MRI Suffolk (n = 3)

ARQ

−/−/−

+/−/−

ND

Atypical scrapie (n = 7)

ARQ (n = 5) or ARR (n = 2)

−/−/−/−/−/−

−/−/−/−/−/−

−/−/−/−/−/−

  1. n = number of animals tested. Samples were tested in duplicate in separate assays *AFRQ/AFRQ substrate where F represents amino acid at position 141. The AFRQ/AFRQ genotype is more commonly associated with atypical scrapie [19]. ND = not done. +/− symbols show the amplification outcome for each animal.
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BMC Veterinary Research

ISSN: 1746-6148

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