PrPd immunolabelling in cerebellum and frontal cortex of classical and atypical BSE cases. Immunolabelling with mAb R145. a-c) Cerebellum of C-type BSE (intracerebrally inoculated case 163/95; a), L-type BSE (L1; b) and H-type BSE (H3; c). e-f) Frontal cortex of C-type BSE (163/95; d), L-type BSE (L3; e), and H-type BSE (H3; f). Of particular interest in the cerebellum is the diffuse and even involvement of both the molecular and granular layers in L-type BSE, while in the cerebellum of the H-type BSE case the most pronounced labelling is in the white matter. In the cortex small aggregated deposits, mostly in the white matter, predominate in the L-type BSE case, while the H-type BSE case resembles the classical BSE case with stellate forms throughout the cortical grey matter.