Identification of myeloid derived suppressor cells in the peripheral blood of tumor bearing dogs

BMC Veterinary Research

Table 2 Comparison of percent of cells positive for CD11b/CADO48A by gate of control and tumor-bearing dogs

Control	Mean	Median	Min	Max
Ungated	31.9±14.4	27.2	12.6	58.2
R1	28.4±10.3	24.4	10.9	50.6
P1	27.5±10.1	23.6	10.6	49.0
P2	24.2±09.2	20.8	8.6	45.3
P3	4.6±2.8	4.0	1.5	13.4
P4	3.6±1.7*	3.0	1.3	7.7
*Tumor*
Ungated	33.7±15.0	29.3	11.4	72.3
R1	30.0±14.1	26.9	8.5	66.9
P1	29.1±14.0	26.0	7.2	65.2
P2	25.5±12.8	22.5	8.1	59.6
P3	4.5±3.6	3.5	1.2	20.3
P4	7.9±3.0*	3.7	1.1	12.7

The percentage of cells staining positive for CD11b and CADO48A are displayed for each gate analyzed for both the control and tumor-bearing populations. Cells from the P4 gate of the tumor bearing dogs were found to be elevated as compared to the healthy control dogs. No other statistical differences were seen in the other gates analyzed. An * denotes statistical significance (P<0.05). All values are expressed as a percentage of all cells analyzed by flow cytometry.

ISSN: 1746-6148