Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis

Table 6 Effect of analgesic treatment on dog activity measured using an accelerometer

	ABT-116 (n=13)	Carprofen (n=11)	Tramadol (n=12)	Placebo (n=12)
Total activity	9.7 ± 24.2	2.7 ± 9.9	−6.6 (−22.5, 36.9)^a	−1.2 ± 18.4
Statistical Power	0.24	0.10
Sample Size for Power > 0.8	n = 59	n = 204
Daytime activity	5.8 ± 25.2	5.5 ± 11.3	−4.9 (−22.6, 37.8)^a	−0.5 ± 18.1
Statistical Power	0.11	0.16
Sample Size for Power > 0.8	n = 185	n = 93
Nighttime activity	58.4 ± 97.4**	−23.4 ± 23.8**	3.0 ± 38.7^b	−4.3 ± 44.8
Statistical Power	0.84	0.3	0.09
Sample Size for Power > 0.8	N/A	n = 41	n = 275

Note: Daytime activity - 6 am to 10 pm; Nighttime activity - 10 pm to 6 am. Data represent percentage change in Week 3 of the trial, compared with the baseline week. Power analysis results compare each treatment group with placebo. Significance of changes in activity from baseline to end of the trial is indicated as follows: ** - P ≤ 0.01.^aData for Total activity and Daytime activity in the Tramadol group were not normally distributed. ^bOne dog in Tramadol group was excluded from nighttime activity analysis because the owner removed the accelerometer during this period, so n = 11 in this cell.

ISSN: 1746-6148