Skip to main content

Table 3 Gene ontologies of the human orthologs of differentially expressed equine plasma proteins

From: Plasma proteomics shows an elevation of the anti-inflammatory protein APOA-IV in chronic equine laminitis

Spot

Gene Name

Expression

Molecular Function

KEGG Pathway

980

alpha-2-macroglobulin

Up-regulated

Serine-type endopeptidase inhibitor activity, growth factor binding, cytokine binding, chemokine binding

Complement and coagulation cascades

980

angiotensinogen

Up-regulated

Serine-type endopeptidase inhibitor activity, growth factor activity, acetyltransferase activator activity, angiotensin receptor binding

Renin-angiotensin system

1299

apolipoprotein A-IV

Up-regulated

Phospholipid binding, antioxidant activity, cholesterol transporter activity

 

1272

coagulation factor X

Down-regulated

Serine-type endopeptidase activity

Complement and coagulation cascades

836

fibrinogen beta chain

Down-regulated

Protein binding, bridging

Complement and coagulation cascades

1056, 1057, 1083

fibrinogen gamma chain

Down-regulated

Protein binding, bridging

Complement and coagulation cascades

836

IgM

Down-regulated

Antigen binding

 

1056

IgA

Down-regulated

Antigen binding

 

819

kininogen 1

Down-regulated

Pattern binding, cysteine-type endopeptidase inhibitor activity, heparin binding

Complement and coagulation cascades

819

protein S, alpha (vitronectin)

Down-regulated

Endopeptidase inhibitor activity, calcium ion binding

Complement and coagulation cascades

457

alpha-1 antitrypsin

Down-regulated

Serine-type endopeptidase inhibitor activity

Complement and coagulation cascades

836, 980

antithrombin

Down-regulated (836), Up-regulated (980)

Pattern binding, serine-type endopeptidase inhibitor activity, heparin binding

Complement and coagulation cascades

1083

alpha-2 antiplasmin

Down-regulated

Serine-type endopeptidase inhibitor activity

Complement and coagulation cascades

462, 819

C1 inhibitor

Down-regulated

Complement binding, serine-type endopeptidase inhibitor activity

Complement and coagulation cascades

457

alpha-2-HS-glycoprotein

Down-regulated

Cysteine-type endopeptidase inhibitor activity, protein tyrosine kinase inhibitor activity

 

1056, 1057, 1083

fetuin B

Down-regulated

Cysteine-type endopeptidase inhibitor activity

 

1272, 1299

similar to Complement C3 precursor

Down-regulated (1272), Up-regulated (1299)

Endopeptidase inhibitor activity

Complement and coagulation cascades