TY - JOUR AU - Suzuki, Shuji AU - Fukushima, Ryuji AU - Ishikawa, Taisuke AU - Yamamoto, Yuta AU - Hamabe, Lina AU - Kim, Soomin AU - Yoshiyuki, Rieko AU - Machida, Noboru AU - Tanaka, Ryou PY - 2012 DA - 2012/09/18 TI - Comparative effects of amlodipine and benazepril on Left Atrial Pressure in Dogs with experimentally-induced Mitral Valve Regurgitation JO - BMC Veterinary Research SP - 166 VL - 8 IS - 1 AB - One of the purposes of treatment for dogs with mitral regurgitation (MR) is lowering left atrial pressure (LAP). There has been few study of the amlodipine in dogs with MR and amlodipine’s effect on LAP has not been fully evaluated in a quantitative manner because of difficulties in directly measuring LAP. The objective of our study was to compare the short-term effects of amlodipine (0.2 mg/kg PO q12h) vs benazepril (0.5 mg/kg PO q12h), on LAP and echocardiographic parameters in five beagle dogs with experimentally-induced MR. LAP of eight dogs that has own control were measured using radiotelemetry system at baseline and again on days 1, 2, 3, 4, 5, 6, 7 of the drug administration. SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-166 DO - 10.1186/1746-6148-8-166 ID - Suzuki2012 ER -