TY - JOUR AU - Fugazzola, Maria AU - Barton, Ann-Kristin AU - Niedorf, Frank AU - Kietzmann, Manfred AU - Ohnesorge, Bernhard PY - 2012 DA - 2012/09/10 TI - Non-genomic action of beclomethasone dipropionate on bronchoconstriction caused by leukotriene C4in precision cut lung slices in the horse JO - BMC Veterinary Research SP - 160 VL - 8 IS - 1 AB - Glucocorticoids have been proven to be effective in the therapy of recurrent airway obstruction (RAO) in horses via systemic as well as local (inhalative) administration. Elective analysis of the effects of this drug on bronchoconstriction in viable lung tissue offers an insight into the mechanism of action of the inflammatory cascade occurring during RAO which is still unclear. The mechanism of action of steroids in treatment of RAO is thought to be induced through classical genomic pathways. We aimed at electively studying the effects of the glucocorticoid beclomethasone dipropionate on equine precision-cut lung slices (PCLS). SN - 1746-6148 UR - https://doi.org/10.1186/1746-6148-8-160 DO - 10.1186/1746-6148-8-160 ID - Fugazzola2012 ER -