Table 5 Genes involved in over-manifested cellular pathways in macrophages grown as a co-culture with canine mammary cancer cells
Pathway | number of genes | P-value |
|---|---|---|
Angiogenesis | 13 | 1.17E-04 |
p53 pathway feedback loops 2 | 6 | 2.16E-04 |
Wnt signaling pathway | 17 | 2.90E-04 |
Alzheimer disease-presenilin pathway | 9 | 1.04E-03 |
Cadherin signaling pathway | 9 | 1.55E-03 |
p53 pathway | 8 | 1.63E-03 |
Plasminogen activating cascade | 3 | 2.84E-03 |
TGF-beta signaling pathway | 8 | 5.07E-03 |
Inflammation mediated by chemokine and cytokine signaling pathway | 12 | 9.09E-03 |
Arginine biosynthesis | 2 | 1.29E-02 |
Alzheimer disease-amyloid secretase pathway | 5 | 1.77E-02 |
Alpha adrenergic receptor signaling pathway | 3 | 2.68E-02 |
Metabotropic glutamate receptor group I pathway | 3 | 3.95E-02 |
FGF signaling pathway | 6 | 4.05E-02 |
Succinate to proprionate conversion | 1 | 4.16E-02 |
PLP biosynthesis | 1 | 4.16E-02 |
Endothelin signaling pathway | 5 | 4.29E-02 |
Muscarinic acetylcholine receptor 1 and 3 signaling pathway | 4 | 4.67E-02 |