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Table 4 Genes involved in over-manfested cellular pathways in canine mammary cancer cells grown as a co-culture with macrophages

From: Global gene expression profiles of canine macrophages and canine mammary cancer cells grown as a co-culture in vitro

Pathway

number of genes

P-value

Inflammation mediated by chemokine and cytokine signaling pathway

21

1.81E-11

Toll receptor signaling pathway

7

9.44E-06

B cell activation

7

6.80E-05

Purine metabolism

3

1.04E-04

T cell activation

8

1.60E-04

Acetate utilization

2

6.87E-04

Apoptosis signaling pathway

6

3.86E-03

Adenine and hypoxanthine salvage pathway

2

8.65E-03

Interleukin signaling pathway

6

8.68E-03

Plasminogen activating cascade

2

1.19E-02

5-Hydroxytryptamine degredation

2

2.19E-02

Lysine biosynthesis

1

2.48E-02

Salvage pyrimidine deoxyribonucleotides

1

3.69E-02

PDGF signaling pathway

5

3.99E-02

Methylcitrate cycle

1

4.89E-02

  1. The list of over-manifested cellular PANTHER pathways in cancer cells grown as co-cultures with macrophages. The binomial test for each PANTHER pathway was used