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Table 3 Up/down-regulated genes in macrophages grown as a co-culture with canine mammary cancer cells

From: Global gene expression profiles of canine macrophages and canine mammary cancer cells grown as a co-culture in vitro

No Fold change Gene symbol Gene name
1 ↑5.78 ABCC5 ABCC5
2 ↑3.17 ANXA2 Annexin A2
3 ↑3.22 ASPM Abnormal spindle-like microcephaly-associated protein homolog
4 ↑3.0 BGN Biglycan
5 ↑5.83 CAV1 Caveolin-1
6 ↑4.04 CAV2 Caveolin-2
7 ↑3.47 CCL20 CCL20
8 ↑3.15 COL1A1 Collagen alpha-1(I) chain
9 ↑4.51 CSF2 Granulocyte-macrophage colony-stimulating factor
10 ↑4.28 CXCL10 C-X-C motif chemokine 10
11 ↑4.06 EGFR EGFR
12 ↑4.66 FZD6 Frizzled-6
13 ↑4.29 GATA6 GATA6
14 ↑3.79 IL12A Interleukin-12 subunit alpha
15 ↑3.63 IL13RA2 Interleukin-13 receptor alpha-2 chain
16 ↑5.39 MMP3 Stromelysin-1
17 ↑4.58 MYC Myc proto-oncogene protein
18 ↑3.51 OAT OAT
19 ↑6.54 PFKM 6-phosphofructokinase, muscle type
20 ↑3.86 PTPLA Protein-tyrosine phosphatase-like member A
21 ↑3.36 RAD51 DNA repair protein RAD51 homolog 1
22 ↑4.86 RHPN2 Rhophilin-2
23 ↑3.05 RPL23 60S ribosomal protein L23
24 ↑3.1 RPS17 40S ribosomal protein S17
25 ↑3.54 RPS18 40S ribosomal protein S18
26 ↑4.87 UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats
27 ↑5.11 Wnt5b wingless-type MMTV integration site family member 5b
28 ↑3.78 Wnt7a wingless-type MMTV integration site family member 7a
29 ↑4.51 Wnt7b wingless-type MMTV integration site family member 7b
30 ↑4.11 YES1 Proto-oncogene tyrosine-protein kinase Yes
31 ↓3.63 ANPEP Aminopeptidase N
32 ↓3.27 APOE Apolipoprotein E
33 ↓5.73 C5AR1 C5a anaphylatoxin chemotactic receptor
34 ↓5.24 CCL13 C-C motif chemokine 13
35 ↓3.33 CCL2 C-C motif chemokine 2
36 ↓3.36 CCR1 CCR1
37 ↓3.73 CCR5 C-C chemokine receptor type 5
38 ↓3.66 CD86 CD86
39 ↓3.1 CTSK Cathepsin K
40 ↓3.08 CXCR7 C-X-C chemokine receptor type 7
41 ↓3.84 DHDH dehydrogenase
42 ↓4.1 EDNRB Endothelin B receptor
43 ↓4.14 HTR7 HTR7
44 ↓3.47 IL18 Interleukin-18
45 ↓3.15 IL1B Interleukin-1 beta
46 ↓3.1 KCNJ2 Inward rectifier potassium channel 2
47 ↓3.61 MMP9 Matrix metalloproteinase-9
48 ↓4.72 MYH7 Myosin-7
49 ↓4.19 OR04A01 olfactory receptor
50 ↓3.64 PDPN Podoplanin
51 ↓3.04 SLC11A1 Natural resistance-associated macrophage protein 1
52 ↓3.08 SLC46A2 Thymic stromal cotransporter homolog
53 ↓4.09 SLC8A1 Sodium/calcium exchanger 1
54 ↓3.15 TLR2 Toll-like receptor 2
55 ↓3.11 TLR4 Toll-like receptor 4
  1. The list of up- (↑) and down- (↓) regulated genes in macrophages grown as co-culture with canine mammary cancer cells. The unpaired t-test with Benjamin-Hochberg FDR < 5% (false discovery rate) correction (with p value cut-off < 0.01) (Gene Spring, Agilent, USA) and further PANTHER analysis were conducted