Table 3 Up/down-regulated genes in macrophages grown as a co-culture with canine mammary cancer cells

1

↑5.78

ABCC5

ABCC5

2

↑3.17

ANXA2

Annexin A2

3

↑3.22

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

4

↑3.0

BGN

Biglycan

5

↑5.83

CAV1

Caveolin-1

6

↑4.04

CAV2

Caveolin-2

7

↑3.47

CCL20

CCL20

8

↑3.15

COL1A1

Collagen alpha-1(I) chain

9

↑4.51

CSF2

Granulocyte-macrophage colony-stimulating factor

10

↑4.28

CXCL10

C-X-C motif chemokine 10

11

↑4.06

EGFR

EGFR

12

↑4.66

FZD6

Frizzled-6

13

↑4.29

GATA6

GATA6

14

↑3.79

IL12A

Interleukin-12 subunit alpha

15

↑3.63

IL13RA2

Interleukin-13 receptor alpha-2 chain

16

↑5.39

MMP3

Stromelysin-1

17

↑4.58

MYC

Myc proto-oncogene protein

18

↑3.51

OAT

OAT

19

↑6.54

PFKM

6-phosphofructokinase, muscle type

20

↑3.86

PTPLA

Protein-tyrosine phosphatase-like member A

21

↑3.36

RAD51

DNA repair protein RAD51 homolog 1

22

↑4.86

RHPN2

Rhophilin-2

23

↑3.05

RPL23

60S ribosomal protein L23

24

↑3.1

RPS17

40S ribosomal protein S17

25

↑3.54

RPS18

40S ribosomal protein S18

26

↑4.87

UACA

Uveal autoantigen with coiled-coil domains and ankyrin repeats

27

↑5.11

Wnt5b

wingless-type MMTV integration site family member 5b

28

↑3.78

Wnt7a

wingless-type MMTV integration site family member 7a

29

↑4.51

Wnt7b

wingless-type MMTV integration site family member 7b

30

↑4.11

YES1

Proto-oncogene tyrosine-protein kinase Yes

31

↓3.63

ANPEP

Aminopeptidase N

32

↓3.27

APOE

Apolipoprotein E

33

↓5.73

C5AR1

C5a anaphylatoxin chemotactic receptor

34

↓5.24

CCL13

C-C motif chemokine 13

35

↓3.33

CCL2

C-C motif chemokine 2

36

↓3.36

CCR1

CCR1

37

↓3.73

CCR5

C-C chemokine receptor type 5

38

↓3.66

CD86

CD86

39

↓3.1

CTSK

Cathepsin K

40

↓3.08

CXCR7

C-X-C chemokine receptor type 7

41

↓3.84

DHDH

dehydrogenase

42

↓4.1

EDNRB

Endothelin B receptor

43

↓4.14

HTR7

HTR7

44

↓3.47

IL18

Interleukin-18

45

↓3.15

IL1B

Interleukin-1 beta

46

↓3.1

KCNJ2

Inward rectifier potassium channel 2

47

↓3.61

MMP9

Matrix metalloproteinase-9

48

↓4.72

MYH7

Myosin-7

49

↓4.19

OR04A01

olfactory receptor

50

↓3.64

PDPN

Podoplanin

51

↓3.04

SLC11A1

Natural resistance-associated macrophage protein 1

52

↓3.08

SLC46A2

Thymic stromal cotransporter homolog

53

↓4.09

SLC8A1

Sodium/calcium exchanger 1

54

↓3.15

TLR2

Toll-like receptor 2

55

↓3.11

TLR4

Toll-like receptor 4