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Table 2 Up/down-regulated genes in canine mammary cancer cell lines grown as co-culture with macrophages

From: Global gene expression profiles of canine macrophages and canine mammary cancer cells grown as a co-culture in vitro

No. Fold change Gene symbol Gene name
1 ↑3.25 ANPEP Aminopeptidase N
2 ↑3.83 ATP6V0E1 V-type proton ATPase subunit e 1
3 ↑4.98 C5AR1 C5a anaphylatoxin chemotactic receptor
4 ↑4.86 CCL2 C-C motif chemokine 2
5 ↑5.23 CCL3 C-C motif chemokine 3
6 ↑4.28 CCL4 C-C motif chemokine 4
7 ↑3.99 CCL5 C-C motif chemokine 5
8 ↑3.91 CCL8 C-C motif chemokine 8
9 ↑3.03 CCR1 CCR1
10 ↑3.66 CCR5 C-C chemokine receptor type 5
11 ↑4.47 CD163 Soluble CD163
12 ↑3.55 CD40 Tumor necrosis factor receptor superfamily member 5
13 ↑4.89 CD80 CD80
14 ↑4.31 CD86 CD86
15 ↑3.38 COX17 Cytochrome c oxidase copper chaperone
16 ↑3.62 CSF2 Granulocyte-macrophage colony-stimulating factor
17 ↑3.53 CSF3 Granulocyte colony-stimulating factor
18 ↑3.68 CSF1R Colony stimulating factor receptor 1
19 ↑3.09 CTSC Dipeptidyl-peptidase 1 light chain
20 ↑5.06 CTSK Cathepsin K
21 ↑5.92 CTSS Cathepsin S
22 ↑3.5 CXCR7 C-X-C chemokine receptor type 7
23 ↑3.26 DLA-64 DLA-64
24 ↑3.26 EMR1 EMR1
25 ↑3.31 FTH1 Ferritin heavy chain
26 ↑3.1 FTL Ferritin light chain
27 ↑5.25 IL1A Interleukin-1 alpha
28 ↑5.07 IL1B Interleukin-1 beta
29 ↑3.45 IL6 Interleukin-6
30 ↑5.6 IL8 Interleukin-8
31 ↑3.09 MMP9 Matrix metalloproteinase-9
32 ↑4.83 MX1 Interferon-induced GTP-binding protein Mx1
33 ↑3.34 NPC2 Epididymal secretory protein E1
34 ↑3.19 OOEP Oocyte-expressed protein
35 ↑3.6 PLA2G7 Platelet-activating factor acetylhydrolase
36 ↑3.23 PSAP Pulmonary surfactant-associated protein A
37 ↑4.84 PSMB8 Proteasome subunit beta type-8
38 ↑3.57 PSMB9 Proteasome subunit beta type
39 ↑3.74 PTGES Prostaglandin E synthase
40 ↑3.35 SLAMF1 Signaling lymphocytic activation molecule
41 ↑3.34 SYK SYK
42 ↑4.64 TLR2 Toll-like receptor 2
43 ↑3.55 TLR4 TLR4
44 ↓3.11 RXRB Retinoic acid receptor RXR-beta
45 ↓3.17 SLC5A3 Sodium/myo-inositol cotransporter
46 ↓3.06 MSX2 Homeobox protein MSX-2
47 ↓5.17 KRT13 Keratin 13
  1. The list of up- (↑) and down- (↓) regulated genes in canine mammary cancer cell lines grown as co-culture with macrophages. The unpaired t-test with Benjamin-Hochberg FDR < 5% (false discovery rate) correction (with p value cut-off < 0.01) (Gene Spring, Agilent, USA) and further PANTHER analysis were conducted