Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia

Table 1 Mean plasma pharmacokinetic parameters for meloxicam after IV administration at 0.5 mg/kg bodyweight determined using a two- compartment model

Parameter	Units	Mean	Standard error
V_c	mL/kg	94.88	9.04
V₂	mL/kg	99.07	7.85
V_ss	mL/kg	193.94	10.34
CL	mL/h/kg	6.64	0.76
CLD₂	mL/h/kg	225.18	47.43
T_½α	hr	0.22	0.087
T_½β	hr	21.86	3.03
AUC	hr*ug/mL	81.02	10.58
MRT	hr	31.24	4.37
K₁₀	1/h	0.075	0.012
K₁₂	1/h	2.70	0.78
K₂₁	1/h	2.20	0.39

V_c, - volume of the central compartment; V₂ - volume of the peripheral compartment; V_ss- apparent volume of distribution at steady-state; CL - total body clearance; CLD_2: - distributional clearance from the central compartment to the peripheral compartment; T_½α and T_½β half-lives for the distribution phases; AUC- area under the time-concentration curve; MRT- mean residence time of the drug in the body; k₁₂ and k₂₁ - μ-rate constants for the drug’s movement between the central and peripheral compartments; and k₁₀ - elimination rate constant.

ISSN: 1746-6148